Organ growth and size are finely tuned by intrinsic and extrinsic signaling molecules. In Drosophila, the BMP family member Dpp is produced in a limited set of imaginal disc cells and functions as a classic morphogen to regulate pattern and growth by diffusing throughout imaginal discs. However, the role of TGFb/Activin-like ligands in disc growth control remains ill-defined. Here, we demonstrate that Myoglianin (Myo), an Activin family member, and a close homolog of mammalian Myostatin (Mstn), is a muscle-derived extrinsic factor that uses canonical dSmad2-mediated signaling to regulate wing size. We propose that Myo is a myokine that helps mediate an allometric relationship between muscles and their associated appendages.
Bibliographical noteFunding Information:
We would like to thank MaryJane O?Connor, Heidi Bretscher, Tom Neufeld, Jeff Simon, and Jim Ervasti for comments on the manuscript and valuable feedback on the project. Ashley Arthur conducted the experiment for Figure 2?figure supplement 1. We also thank Louise Lu for quantification of babo isoform primer amplification efficiency. Bloomington Drosophila Stock Center for numerous fly lines. Ci-GAL4 and hh-GAL4 lines were a gift from Herman Steller.
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural