Mutagenicity of K-region derivatives of 1-nitropyrene; remarkable activity of 1- and 3-nitro-5H-phenanthro[4,5-bcd]pyran-5-one

Medicine & Life Sciences

• 1-nitropyrene 100%
• pyrene 27%
• Lactones 24%
• quinone 23%
• 4,5-dihydro-4,5-dihydroxy-1-nitropyrene 15%
• Pyrans 10%
• trans-1,2-dihydro-1,2-naphthalenediol 10%
• Quinones 9%
• 3-nitro-5H-phenanthro(4,5-bcd)pyran-5-one 9%
• 1-nitro-5H-phenanthro(4,5-bcd)pyran-5-one 9%
• Esterification 8%
• Metabolic Activation 7%

Chemical Compounds

• 1-Nitropyrene 90%
• Lactone 23%
• Strain 17%
• Pyrene 15%
• Mammalian Metabolite 14%
• Metabolic Activation 10%
• Quinone 7%
• Esterification 7%
• Plate Like Crystal 6%
• Dose 6%