Mutations in the amino terminus of herpes simplex virus type 1 gL can reduce cell-cell fusion without affecting gH/gL trafficking

Wenbo Zhou, Feng Chen, Yuri Klyachkin, Yuk Y Sham, Robert J Geraghty

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The gH/gL heterodimer represents two of the four herpes simplex virus glycoproteins necessary and sufficient for membrane fusion. We generated deletions and point mutations covering gL residues 24 to 43 to investigate that region's role in gH/gL intracellular trafficking and in membrane fusion. Multiple mutants displayed a 40 to 60% reduction in cell fusion with no effect on gH/gL trafficking. The amino terminus of gL plays an important role in the gH/gL contribution to membrane fusion.

Original languageEnglish (US)
Pages (from-to)739-744
Number of pages6
JournalJournal of virology
Volume88
Issue number1
DOIs
StatePublished - Jan 2014

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