TY - JOUR
T1 - Negative association between schizophrenia and rheumatoid arthritis
AU - Vinogradov, S.
AU - Gottesman, I. I.
AU - Moises, H. W.
AU - Nicol, S.
PY - 1991
Y1 - 1991
N2 - Persuasive evidence has accumulated demonstrating a strong negative association between rheumatoid arthritis and schizophrenia at the population level. Explanations for this phenomenon have taken into consideration immunological, biochemical, and genetic factors. In this article, we examine these and other factors in closer detail. We then propose hypotheses at the molecular level that might account for the negative association between the two diseases. These hypotheses may provide clues for our colleagues in molecular biology as they search for candidate genes, "anti-genes," and molecular mechanisms relevant to schizophrenia.
AB - Persuasive evidence has accumulated demonstrating a strong negative association between rheumatoid arthritis and schizophrenia at the population level. Explanations for this phenomenon have taken into consideration immunological, biochemical, and genetic factors. In this article, we examine these and other factors in closer detail. We then propose hypotheses at the molecular level that might account for the negative association between the two diseases. These hypotheses may provide clues for our colleagues in molecular biology as they search for candidate genes, "anti-genes," and molecular mechanisms relevant to schizophrenia.
UR - http://www.scopus.com/inward/record.url?scp=0026336348&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026336348&partnerID=8YFLogxK
U2 - 10.1093/schbul/17.4.669
DO - 10.1093/schbul/17.4.669
M3 - Article
C2 - 1805356
AN - SCOPUS:0026336348
SN - 0586-7614
VL - 17
SP - 669
EP - 678
JO - Schizophrenia bulletin
JF - Schizophrenia bulletin
IS - 4
ER -