Nephrotoxicity due to intermediate-dose methotrexate without rescue in an obese adolescent with acute lymphoblastic leukemia

Martin Sauer; Nancy Rydholm; John Piatkowski; Victor Lewis; Marie Steiner

doi:10.1080/08880010252825722

Nephrotoxicity due to intermediate-dose methotrexate without rescue in an obese adolescent with acute lymphoblastic leukemia

Martin Sauer, Nancy Rydholm, John Piatkowski, Victor Lewis, Marie Steiner

Pediatrics - Hematology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Toxicity from intermediate-dose methotrexate (MTX) is unusual. A severely obese adolescent with acute lymphoblastic leukemia experienced significant, delayed nephrotoxicity from intermediate-dose MTX. Altered MTX disposition may occur as a consequence of other ingestions or conditions such as obesity. The use of radioisotope renography established the diagnosis and followed the resolution of the patient's MTX-induced nephrotoxicity.

Original language	English (US)
Pages (from-to)	135-140
Number of pages	6
Journal	Pediatric hematology and oncology
Volume	19
Issue number	2
DOIs	https://doi.org/10.1080/08880010252825722
State	Published - 2002

Keywords

Acute lymphoblastic leukemia
Methotrexate
Nephrotoxicity
Obesity
Renogram

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Nephrotoxicity due to intermediate-dose methotrexate without rescue in an obese adolescent with acute lymphoblastic leukemia",

abstract = "Toxicity from intermediate-dose methotrexate (MTX) is unusual. A severely obese adolescent with acute lymphoblastic leukemia experienced significant, delayed nephrotoxicity from intermediate-dose MTX. Altered MTX disposition may occur as a consequence of other ingestions or conditions such as obesity. The use of radioisotope renography established the diagnosis and followed the resolution of the patient's MTX-induced nephrotoxicity.",

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AU - Sauer, Martin

AU - Rydholm, Nancy

AU - Piatkowski, John

AU - Lewis, Victor

AU - Steiner, Marie

PY - 2002

Y1 - 2002

N2 - Toxicity from intermediate-dose methotrexate (MTX) is unusual. A severely obese adolescent with acute lymphoblastic leukemia experienced significant, delayed nephrotoxicity from intermediate-dose MTX. Altered MTX disposition may occur as a consequence of other ingestions or conditions such as obesity. The use of radioisotope renography established the diagnosis and followed the resolution of the patient's MTX-induced nephrotoxicity.

AB - Toxicity from intermediate-dose methotrexate (MTX) is unusual. A severely obese adolescent with acute lymphoblastic leukemia experienced significant, delayed nephrotoxicity from intermediate-dose MTX. Altered MTX disposition may occur as a consequence of other ingestions or conditions such as obesity. The use of radioisotope renography established the diagnosis and followed the resolution of the patient's MTX-induced nephrotoxicity.

KW - Acute lymphoblastic leukemia

KW - Methotrexate

KW - Nephrotoxicity

KW - Obesity

KW - Renogram

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JF - Pediatric hematology and oncology

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ER -

Nephrotoxicity due to intermediate-dose methotrexate without rescue in an obese adolescent with acute lymphoblastic leukemia

Abstract

Keywords

UN SDGs

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