TY - JOUR
T1 - Neurocardiogenic syncope
T2 - Latest pharmacological therapies
AU - Chen, Lin Y.
AU - Shen, Win Kuang
PY - 2006/6
Y1 - 2006/6
N2 - Neurocardiogenic syncope is a neurally mediated disorder and is a common cause of syncope. The goal of treatment is to prevent recurrences with the aim of improving quality of life and reducing morbidity. Reassurance, in some cases, may suffice. In others, augmenting central blood volume by increasing fluid and/or salt intake is effective. The role of non-pharmacological physical manoeuvres is increasingly recognised, given the increasing clinical trial data supporting their efficacy. This review summarises the clinical evidence for a variety of pharmacological agents. Of these, midodrine appears to have yielded the most consistent favourable outcome. Its use, however, should be reserved for patients with recurrent and refractory syncope.
AB - Neurocardiogenic syncope is a neurally mediated disorder and is a common cause of syncope. The goal of treatment is to prevent recurrences with the aim of improving quality of life and reducing morbidity. Reassurance, in some cases, may suffice. In others, augmenting central blood volume by increasing fluid and/or salt intake is effective. The role of non-pharmacological physical manoeuvres is increasingly recognised, given the increasing clinical trial data supporting their efficacy. This review summarises the clinical evidence for a variety of pharmacological agents. Of these, midodrine appears to have yielded the most consistent favourable outcome. Its use, however, should be reserved for patients with recurrent and refractory syncope.
KW - Midodrine
KW - Neurocardiogenic syncope
KW - β-blockers
UR - http://www.scopus.com/inward/record.url?scp=33745466150&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745466150&partnerID=8YFLogxK
U2 - 10.1517/14656566.7.9.1151
DO - 10.1517/14656566.7.9.1151
M3 - Review article
C2 - 16732702
AN - SCOPUS:33745466150
SN - 1465-6566
VL - 7
SP - 1151
EP - 1162
JO - Expert Opinion on Pharmacotherapy
JF - Expert Opinion on Pharmacotherapy
IS - 9
ER -