TY - JOUR
T1 - Neuropsychological outcomes of U.S. Veterans with report of remote blast-related concussion and current psychopathology
AU - Nelson, Nathaniel W.
AU - Hoelzle, James B.
AU - Doane, Bridget M.
AU - McGuire, Kathryn A.
AU - Ferrier-Auerbach, Amanda G.
AU - Charlesworth, Molly J.
AU - Lamberty, Gregory J.
AU - Polusny, Melissa A.
AU - Arbisi, Paul A.
AU - Sponheim, Scott R.
PY - 2012/9
Y1 - 2012/9
N2 - This study explored whether remote blast-related MTBI and/or current Axis I psychopathology contribute to neuropsychological outcomes among OEF/OIF veterans with varied combat histories. OEF/OIF veterans underwent structured interviews to evaluate history of blast-related MTBI and psychopathology and were assigned to MTBI (n = 18), Axis I (n = 24), Co-morbid MTBI/Axis I (n = 34), or post-deployment control (n = 28) groups. A main effect for Axis I diagnosis on overall neuropsychological performance was identified (F(3,100) = 4.81; p =.004), with large effect sizes noted for the Axis I only (d =.98) and Co-morbid MTBI/Axis I (d =.95) groups relative to the control group. The latter groups demonstrated primary limitations on measures of learning/memory and processing speed. The MTBI only group demonstrated performances that were not significantly different from the remaining three groups. These findings suggest that a remote history of blast-related MTBI does not contribute to objective cognitive impairment in the late stage of injury. Impairments, when present, are subtle and most likely attributable to PTSD and other psychological conditions. Implications for clinical neuropsychologists and future research are discussed.
AB - This study explored whether remote blast-related MTBI and/or current Axis I psychopathology contribute to neuropsychological outcomes among OEF/OIF veterans with varied combat histories. OEF/OIF veterans underwent structured interviews to evaluate history of blast-related MTBI and psychopathology and were assigned to MTBI (n = 18), Axis I (n = 24), Co-morbid MTBI/Axis I (n = 34), or post-deployment control (n = 28) groups. A main effect for Axis I diagnosis on overall neuropsychological performance was identified (F(3,100) = 4.81; p =.004), with large effect sizes noted for the Axis I only (d =.98) and Co-morbid MTBI/Axis I (d =.95) groups relative to the control group. The latter groups demonstrated primary limitations on measures of learning/memory and processing speed. The MTBI only group demonstrated performances that were not significantly different from the remaining three groups. These findings suggest that a remote history of blast-related MTBI does not contribute to objective cognitive impairment in the late stage of injury. Impairments, when present, are subtle and most likely attributable to PTSD and other psychological conditions. Implications for clinical neuropsychologists and future research are discussed.
KW - Cognition
KW - Mild Traumatic Brain Injury
KW - Operation Iraqi Freedom
KW - Post-traumatic Stress Disorder
UR - http://www.scopus.com/inward/record.url?scp=84865994516&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865994516&partnerID=8YFLogxK
U2 - 10.1017/S1355617712000616
DO - 10.1017/S1355617712000616
M3 - Article
C2 - 22687547
AN - SCOPUS:84865994516
SN - 1355-6177
VL - 18
SP - 845
EP - 855
JO - Journal of the International Neuropsychological Society
JF - Journal of the International Neuropsychological Society
IS - 5
ER -