New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2)

Medicine & Life Sciences

• tyrosyl-DNA phosphodiesterase 100%
• High-Throughput Screening Assays 78%
• Fluorescence 45%
• Phosphodiesterase Inhibitors 25%
• Libraries 18%
• Gels 11%
• Crystallography 9%
• Type II DNA Topoisomerase 8%
• Guanidine 8%
• Molecular Structure 8%
• Structure-Activity Relationship 8%
• Running 7%
• Zebrafish 7%
• Inhibitory Concentration 50 6%
• Biochemistry 6%
• DNA Damage 6%
• Neoplasms 4%
• DNA 3%
• Proteins 2%
• Therapeutics 1%

Chemical Compounds

• High Throughput Screening 59%
• Compound Z 44%
• Molecular Scaffold 34%
• Fluorescence 31%
• Crystallography 29%
• Guanidine 28%
• Biochemistry 25%
• Structure-Activity Relationship 23%
• Molecule 19%
• Molecular Structure 19%
• Resistance 17%
• Crystal Structure 13%
• Protein 11%