TY - JOUR
T1 - Non-destructive determination of the coating film thickness by X-ray powder diffractometry and correlation with the dissolution behavior of film-coated tablets
AU - Yamada, Hiroyuki
AU - Terada, Katsuhide
AU - Suryanarayanan, Raj
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/3/11
Y1 - 2010/3/11
N2 - The goal of this project was to determine the effect of the thickness of the coating film on the dissolution behavior of tablets. Commercially available film-coated tablets containing aspirin, acetaminophen and caffeine, were used as the model system. First, a non-destructive X-ray microdiffractometric technique was developed to quantify the thickness of the film-coating in intact tablets. The same tablets were then subjected to dissolution tests. There was an inverse correlation between the cumulative amount of drug in solution at 5 min and the thickness of the coating film. As the coating thickness increased, the initiation of tablet dissolution was delayed, resulting in a decrease in the cumulative amount of drug in solution. Finally, the technique was applied to formulations marketed by different companies. The X-ray microdiffractometric technique has the potential to predict the dissolution behavior of tablets.
AB - The goal of this project was to determine the effect of the thickness of the coating film on the dissolution behavior of tablets. Commercially available film-coated tablets containing aspirin, acetaminophen and caffeine, were used as the model system. First, a non-destructive X-ray microdiffractometric technique was developed to quantify the thickness of the film-coating in intact tablets. The same tablets were then subjected to dissolution tests. There was an inverse correlation between the cumulative amount of drug in solution at 5 min and the thickness of the coating film. As the coating thickness increased, the initiation of tablet dissolution was delayed, resulting in a decrease in the cumulative amount of drug in solution. Finally, the technique was applied to formulations marketed by different companies. The X-ray microdiffractometric technique has the potential to predict the dissolution behavior of tablets.
KW - Coating film thickness
KW - Dissolution
KW - Film-coated tablet
KW - Microdiffractometry
KW - X-ray
UR - http://www.scopus.com/inward/record.url?scp=72149097604&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=72149097604&partnerID=8YFLogxK
U2 - 10.1016/j.jpba.2009.10.003
DO - 10.1016/j.jpba.2009.10.003
M3 - Article
C2 - 19945243
AN - SCOPUS:72149097604
SN - 0731-7085
VL - 51
SP - 952
EP - 957
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
IS - 4
ER -