Non-destructive determination of the coating film thickness by X-ray powder diffractometry and correlation with the dissolution behavior of film-coated tablets

Hiroyuki Yamada, Katsuhide Terada, Raj Suryanarayanan

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The goal of this project was to determine the effect of the thickness of the coating film on the dissolution behavior of tablets. Commercially available film-coated tablets containing aspirin, acetaminophen and caffeine, were used as the model system. First, a non-destructive X-ray microdiffractometric technique was developed to quantify the thickness of the film-coating in intact tablets. The same tablets were then subjected to dissolution tests. There was an inverse correlation between the cumulative amount of drug in solution at 5 min and the thickness of the coating film. As the coating thickness increased, the initiation of tablet dissolution was delayed, resulting in a decrease in the cumulative amount of drug in solution. Finally, the technique was applied to formulations marketed by different companies. The X-ray microdiffractometric technique has the potential to predict the dissolution behavior of tablets.

Original languageEnglish (US)
Pages (from-to)952-957
Number of pages6
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume51
Issue number4
DOIs
StatePublished - Mar 11 2010

Bibliographical note

Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.

Keywords

  • Coating film thickness
  • Dissolution
  • Film-coated tablet
  • Microdiffractometry
  • X-ray

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