Abstract
A significant recent development in functional magnetic resonance imaging (fMRI) is the introduction of event-related fMRI, also known as time-resolved fMRI. Because the exact shape of the MR response in an event-related fMRI experiment is often not known, traditional methods developed for block design experiments, such as t test and correlation analysis, are not well-suited for extracting activated pixels from the event-related data. In this work, a statistical technique based on nonadditive two-way analysis of variance is developed for use in event-related studies. Theoretical and experimental work were carried out for establishing a statistical threshold to determine pixel activation. Experimental studies were performed to demonstrate the utility of this approach.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 406-416 |
| Number of pages | 11 |
| Journal | NeuroImage |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2001 |
Bibliographical note
Funding Information:1Work Supported by the National Institutes of Health (Grants RR08079, RO1MH55346, and R03MH59245), and the Whitaker Foundation (Graduate Fellowships in Biomedical Engineering).