Noroleanane-type triterpenoids from Dolichos trilobus L. and their anti-α-glucosidase activities

Ming Luo, Yan Hong Li, Ya Lu, Yan Yuan, Rong Sheng Ruan, Yong Ming Chuan, Kai Tian, Xiang Zhong Huang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Falcatane A (1) and B (2), 4-oxo-3,24-dinor-2,4-secooleanane- and 3-oxo-24- noroleanane-type triterpenoids, together with seven known triterpenoids involving 2-hydroxy-3-oxo-24-noroleana-1,4,12-trien-28-oic acid (3) and oleanolic acid (4), were separated from the ethyl acetate roots extract of Dolichos trilobus using the column chromatography of silica gel, MCI gel, and Sephadex LH-20. The compounds were determined by analysis of IR, NMR spectroscopic data and mass spectrometry. In the bioassay, all isolates showed varying degree of the α-glucosidase inhibitory activity except compound 2.

Original languageEnglish (US)
Pages (from-to)600-606
Number of pages7
JournalNatural Product Research
Volume35
Issue number4
DOIs
StatePublished - 2021
Externally publishedYes

Bibliographical note

Funding Information:
This work was financially supported by the National Natural Science Foundation of China (NSFC No. 81460535, 21262047), the Yunnan Provincial Applied Basic Research Projects (No. 2017FD122), the Yunnan Provincial Department of Education Science Research Fund Projects (No. 2017YJS058).

Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • Dolichos trilobusL
  • anti-α-glucosidase activity
  • nortriterpenoids

PubMed: MeSH publication types

  • Journal Article

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