Noroleanane-type triterpenoids from Dolichos trilobus L. and their anti-α-glucosidase activities

Ming Luo; Yan Hong Li; Ya Lu; Yan Yuan; Rong Sheng Ruan; Yong Ming Chuan; Kai Tian; Xiang Zhong Huang

doi:10.1080/14786419.2019.1590713

Noroleanane-type triterpenoids from Dolichos trilobus L. and their anti-α-glucosidase activities

Ming Luo, Yan Hong Li, Ya Lu, Yan Yuan, Rong Sheng Ruan, Yong Ming Chuan, Kai Tian, Xiang Zhong Huang

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Falcatane A (1) and B (2), 4-oxo-3,24-dinor-2,4-secooleanane- and 3-oxo-24- noroleanane-type triterpenoids, together with seven known triterpenoids involving 2-hydroxy-3-oxo-24-noroleana-1,4,12-trien-28-oic acid (3) and oleanolic acid (4), were separated from the ethyl acetate roots extract of Dolichos trilobus using the column chromatography of silica gel, MCI gel, and Sephadex LH-20. The compounds were determined by analysis of IR, NMR spectroscopic data and mass spectrometry. In the bioassay, all isolates showed varying degree of the α-glucosidase inhibitory activity except compound 2.

Original language	English (US)
Pages (from-to)	600-606
Number of pages	7
Journal	Natural Product Research
Volume	35
Issue number	4
DOIs	https://doi.org/10.1080/14786419.2019.1590713
State	Published - 2021
Externally published	Yes

Bibliographical note

Funding Information:
This work was financially supported by the National Natural Science Foundation of China (NSFC No. 81460535, 21262047), the Yunnan Provincial Applied Basic Research Projects (No. 2017FD122), the Yunnan Provincial Department of Education Science Research Fund Projects (No. 2017YJS058).

Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

Dolichos trilobusL
anti-α-glucosidase activity
nortriterpenoids

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title = "Noroleanane-type triterpenoids from Dolichos trilobus L. and their anti-α-glucosidase activities",

abstract = "Falcatane A (1) and B (2), 4-oxo-3,24-dinor-2,4-secooleanane- and 3-oxo-24- noroleanane-type triterpenoids, together with seven known triterpenoids involving 2-hydroxy-3-oxo-24-noroleana-1,4,12-trien-28-oic acid (3) and oleanolic acid (4), were separated from the ethyl acetate roots extract of Dolichos trilobus using the column chromatography of silica gel, MCI gel, and Sephadex LH-20. The compounds were determined by analysis of IR, NMR spectroscopic data and mass spectrometry. In the bioassay, all isolates showed varying degree of the α-glucosidase inhibitory activity except compound 2.",

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author = "Ming Luo and Li, {Yan Hong} and Ya Lu and Yan Yuan and Ruan, {Rong Sheng} and Chuan, {Yong Ming} and Kai Tian and Huang, {Xiang Zhong}",

note = "Funding Information: This work was financially supported by the National Natural Science Foundation of China (NSFC No. 81460535, 21262047), the Yunnan Provincial Applied Basic Research Projects (No. 2017FD122), the Yunnan Provincial Department of Education Science Research Fund Projects (No. 2017YJS058). Publisher Copyright: {\textcopyright} 2019 Informa UK Limited, trading as Taylor & Francis Group.",

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AU - Lu, Ya

AU - Yuan, Yan

AU - Ruan, Rong Sheng

AU - Chuan, Yong Ming

AU - Tian, Kai

AU - Huang, Xiang Zhong

N1 - Funding Information: This work was financially supported by the National Natural Science Foundation of China (NSFC No. 81460535, 21262047), the Yunnan Provincial Applied Basic Research Projects (No. 2017FD122), the Yunnan Provincial Department of Education Science Research Fund Projects (No. 2017YJS058). Publisher Copyright: © 2019 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2021

Y1 - 2021

N2 - Falcatane A (1) and B (2), 4-oxo-3,24-dinor-2,4-secooleanane- and 3-oxo-24- noroleanane-type triterpenoids, together with seven known triterpenoids involving 2-hydroxy-3-oxo-24-noroleana-1,4,12-trien-28-oic acid (3) and oleanolic acid (4), were separated from the ethyl acetate roots extract of Dolichos trilobus using the column chromatography of silica gel, MCI gel, and Sephadex LH-20. The compounds were determined by analysis of IR, NMR spectroscopic data and mass spectrometry. In the bioassay, all isolates showed varying degree of the α-glucosidase inhibitory activity except compound 2.

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Noroleanane-type triterpenoids from Dolichos trilobus L. and their anti-α-glucosidase activities

Abstract

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