Falcatane A (1) and B (2), 4-oxo-3,24-dinor-2,4-secooleanane- and 3-oxo-24- noroleanane-type triterpenoids, together with seven known triterpenoids involving 2-hydroxy-3-oxo-24-noroleana-1,4,12-trien-28-oic acid (3) and oleanolic acid (4), were separated from the ethyl acetate roots extract of Dolichos trilobus using the column chromatography of silica gel, MCI gel, and Sephadex LH-20. The compounds were determined by analysis of IR, NMR spectroscopic data and mass spectrometry. In the bioassay, all isolates showed varying degree of the α-glucosidase inhibitory activity except compound 2.
Bibliographical noteFunding Information:
This work was financially supported by the National Natural Science Foundation of China (NSFC No. 81460535, 21262047), the Yunnan Provincial Applied Basic Research Projects (No. 2017FD122), the Yunnan Provincial Department of Education Science Research Fund Projects (No. 2017YJS058).
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- Dolichos trilobusL
- anti-α-glucosidase activity
PubMed: MeSH publication types
- Journal Article