Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties

Clara Cena; Konstantin Chegaev; Silvia Balbo; Loretta Lazzarato; Barbara Rolando; Marta Giorgis; Elisabetta Marini; Roberta Fruttero; Alberto Gasco

doi:10.1016/j.bmc.2008.03.014

Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties

Clara Cena, Konstantin Chegaev, Silvia Balbo, Loretta Lazzarato, Barbara Rolando, Marta Giorgis, Elisabetta Marini, Roberta Fruttero, Alberto Gasco

Environmental Health Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

In this paper, we describe a new class of products in which NO-donor moieties are linked to either the 3-OH (4a-f) or 2-OH group (7a-c) of ascorbic acid (ASA). Log Ps and pK_as of these products were experimentally evaluated. All the compounds were tested for their antioxidant activity on lipidic peroxidation induced by Fe³⁺-ADP/NADPH in lipids of microsomal membranes of rat hepatocytes. Only 3-O series displays antioxidant activity and it seems to be principally dependent on the lipophilicity. Both series trigger in vitro NO-dependent vasodilator properties.

Original language	English (US)
Pages (from-to)	5199-5206
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry
Volume	16
Issue number	9
DOIs	https://doi.org/10.1016/j.bmc.2008.03.014
State	Published - May 1 2008

Bibliographical note

Funding Information:
This work was supported by a MIUR Grant (COFIN 2005).

Keywords

Multitarget drugs
NO-donor antioxidants
NO-donor ascorbic acid derivatives

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AU - Cena, Clara

AU - Chegaev, Konstantin

AU - Balbo, Silvia

AU - Lazzarato, Loretta

AU - Rolando, Barbara

AU - Giorgis, Marta

AU - Marini, Elisabetta

AU - Fruttero, Roberta

AU - Gasco, Alberto

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Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties

Abstract

Bibliographical note

Keywords

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