Novel indole-3-carboxaldehyde analogues: Synthesis and their antioxidant evaluation

Nagaraja Naik, H. Vijay Kumar, N. M. Roopashree

Research output: Contribution to journalArticlepeer-review

Abstract

A series of novel indole-3-carboxaldehyde conjugated with different aryl amines were synthesized and examined for their antioxidant potential to probe the most potent analogues using two in vitro models like 2,2-diphenyl-1- picrylhydrazyl (DPPH) free radical scavenging assay and inhibition of microsomal lipid peroxidation (LPO) assay. Through the compounds showed various degree of activity whereas, compound (5f) displayed superior antioxidant activity relative to other examined analogues and also exhibit more activity than the standard, butylated hydroxy anisole (BHA).

Original languageEnglish (US)
Pages (from-to)783-790
Number of pages8
JournalDer Pharma Chemica
Volume4
Issue number2
StatePublished - 2012
Externally publishedYes

Keywords

  • Antioxidant activity
  • Aryl amines
  • Free radical scavenging
  • Indole-3-carboxaldehyde
  • Microsomal lipid peroxidation

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