Novel inward rectifier blocked by Cd2+ in crayfish muscle

Alfonso Araque; Washington Buño

doi:10.1016/0006-8993(91)91555-F

Novel inward rectifier blocked by Cd²⁺ in crayfish muscle

Alfonso Araque, Washington Buño

Neuroscience

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The characteristics of a voltage- and time-dependent inward rectifying current were examined with voltage clamp techniques in crayfish muscle. The inward current, carried by K⁺, was activated by hyperpolarization. Although this inward current increased with the extracellular K⁺ concentration ([K⁺]_o), the voltage-dependence of the underlying conductance was independent of [K⁺]_o. The current was unaffected by Cs⁺ and Ba²⁺, but was blocked by low concentrations of Cd²⁺. Therefore, this inward rectifier is different than previously described ones.

Original language	English (US)
Pages (from-to)	321-324
Number of pages	4
Journal	Brain Research
Volume	563
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(91)91555-F
State	Published - Nov 1 1991

Bibliographical note

Funding Information:
We would like to thank Drs. M. Gola and C.E Stevens for their suggestions. This work was supported by DGICYT grant to W.B. A.A. is a CajaMadrid fellow.

Keywords

Anomalous rectification
Cd-blockade
Crayfish muscle
Hyperpolarization-activated current
Inward rectifier
K current

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10.1016/0006-8993(91)91555-F

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title = "Novel inward rectifier blocked by Cd2+ in crayfish muscle",

abstract = "The characteristics of a voltage- and time-dependent inward rectifying current were examined with voltage clamp techniques in crayfish muscle. The inward current, carried by K+, was activated by hyperpolarization. Although this inward current increased with the extracellular K+ concentration ([K+]o), the voltage-dependence of the underlying conductance was independent of [K+]o. The current was unaffected by Cs+ and Ba2+, but was blocked by low concentrations of Cd2+. Therefore, this inward rectifier is different than previously described ones.",

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AU - Araque, Alfonso

AU - Buño, Washington

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N2 - The characteristics of a voltage- and time-dependent inward rectifying current were examined with voltage clamp techniques in crayfish muscle. The inward current, carried by K+, was activated by hyperpolarization. Although this inward current increased with the extracellular K+ concentration ([K+]o), the voltage-dependence of the underlying conductance was independent of [K+]o. The current was unaffected by Cs+ and Ba2+, but was blocked by low concentrations of Cd2+. Therefore, this inward rectifier is different than previously described ones.

AB - The characteristics of a voltage- and time-dependent inward rectifying current were examined with voltage clamp techniques in crayfish muscle. The inward current, carried by K+, was activated by hyperpolarization. Although this inward current increased with the extracellular K+ concentration ([K+]o), the voltage-dependence of the underlying conductance was independent of [K+]o. The current was unaffected by Cs+ and Ba2+, but was blocked by low concentrations of Cd2+. Therefore, this inward rectifier is different than previously described ones.

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KW - Cd-blockade

KW - Crayfish muscle

KW - Hyperpolarization-activated current

KW - Inward rectifier

KW - K current

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