TY - JOUR
T1 - Novel phenothiazine analogous
T2 - Synthesis and a new perceptivity into their antioxidant potential
AU - Naik, Nagaraja
AU - Vijay Kumar, Honnaiah
AU - Veena, Vuppugundur
PY - 2012
Y1 - 2012
N2 - Novel series of phenothiazine derivatives obtained by the phenothiazine-aryl amines conjugates via acetyl group was described. The newly synthesized compounds were characterized by spectral and elemental analysis data. The antioxidant activity was assessed using two in vitro methods namely, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and inhibition on human low density lipoprotein (LDL) oxidation assay. All the conjugates exhibited good antioxidant activity whereas, compound 2e having 4-amino-2-methoxyphenol moiety exhibited potent antioxidant activities in both the assays and was found more active than the butylated hydroxy anisole (BHA), a reference antioxidant.
AB - Novel series of phenothiazine derivatives obtained by the phenothiazine-aryl amines conjugates via acetyl group was described. The newly synthesized compounds were characterized by spectral and elemental analysis data. The antioxidant activity was assessed using two in vitro methods namely, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and inhibition on human low density lipoprotein (LDL) oxidation assay. All the conjugates exhibited good antioxidant activity whereas, compound 2e having 4-amino-2-methoxyphenol moiety exhibited potent antioxidant activities in both the assays and was found more active than the butylated hydroxy anisole (BHA), a reference antioxidant.
KW - 10-chloroacetylphenothiazine
KW - Aryl amines
KW - LDL oxidation
KW - Phenothiazine
KW - Radical scavenging activity
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M3 - Article
AN - SCOPUS:84863997097
SN - 0975-5071
VL - 4
SP - 786
EP - 794
JO - Der Pharmacia Lettre
JF - Der Pharmacia Lettre
IS - 3
ER -