Obesity augments calcium-induced increases in skeletal calcium retention in adolescents

Kathleen M. Hill; Michelle M Braun; Kara A. Egan; Berdine R. Martin; Linda D. McCabe; Munro Peacock; George P. McCabe; Connie M. Weaver

doi:10.1210/jc.2010-2709

Obesity augments calcium-induced increases in skeletal calcium retention in adolescents

Kathleen M. Hill, Michelle M Braun, Kara A. Egan, Berdine R. Martin, Linda D. McCabe, Munro Peacock, George P. McCabe, Connie M. Weaver

Food Science and Nutrition

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

CONTEXT: Overweight adolescents have low bone mineral content for weight and are at increased risk for fractures.

OBJECTIVE: The aim was to determine whether overweight and obesity influence the positive relationship between dietary calcium intake and skeletal calcium retention in adolescents.

DESIGN: Analysis of pooled data from calcium balance studies in adolescents.

SETTING: Participants each underwent a 3-wk calcium balance study in a controlled environment.

PARTICIPANTS: Participants included 280 White, Black, and Asian boys (n = 73) and girls (n = 207) ages 10-16 yr.

MAIN OUTCOME MEASURE: The relationship among body mass index (BMI), calcium intake, and calcium retention was modeled using linear regression.

RESULTS: Calcium intake, BMI, sex, race, and age explained 27.9% of the variation in calcium retention. At low calcium intakes, there was no effect of BMI on skeletal calcium retention, but at higher calcium intakes, BMI increased skeletal calcium retention.

CONCLUSIONS: Greater gains in calcium retention occur with increases in calcium intake in adolescents with higher BMI compared with those with lower BMI. Additional studies are needed to investigate whether increasing calcium intake reduces the increased risk of fracture associated with overweight and obesity in adolescents.

Original language	English (US)
Pages (from-to)	2171-2177
Number of pages	7
Journal	The Journal of clinical endocrinology and metabolism
Volume	96
Issue number	7
DOIs	https://doi.org/10.1210/jc.2010-2709
State	Published - Jul 2011

Keywords

Adolescent
African Continental Ancestry Group
Body Mass Index
Body Weight
Bone Density
Bone and Bones/metabolism
Calcium/metabolism
Calcium, Dietary/metabolism
Child
European Continental Ancestry Group
Female
Humans
Male
Obesity/metabolism

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Obesity augments calcium-induced increases in skeletal calcium retention in adolescents",

abstract = "CONTEXT: Overweight adolescents have low bone mineral content for weight and are at increased risk for fractures.OBJECTIVE: The aim was to determine whether overweight and obesity influence the positive relationship between dietary calcium intake and skeletal calcium retention in adolescents.DESIGN: Analysis of pooled data from calcium balance studies in adolescents.SETTING: Participants each underwent a 3-wk calcium balance study in a controlled environment.PARTICIPANTS: Participants included 280 White, Black, and Asian boys (n = 73) and girls (n = 207) ages 10-16 yr.MAIN OUTCOME MEASURE: The relationship among body mass index (BMI), calcium intake, and calcium retention was modeled using linear regression.RESULTS: Calcium intake, BMI, sex, race, and age explained 27.9% of the variation in calcium retention. At low calcium intakes, there was no effect of BMI on skeletal calcium retention, but at higher calcium intakes, BMI increased skeletal calcium retention.CONCLUSIONS: Greater gains in calcium retention occur with increases in calcium intake in adolescents with higher BMI compared with those with lower BMI. Additional studies are needed to investigate whether increasing calcium intake reduces the increased risk of fracture associated with overweight and obesity in adolescents.",

keywords = "Adolescent, African Continental Ancestry Group, Body Mass Index, Body Weight, Bone Density, Bone and Bones/metabolism, Calcium/metabolism, Calcium, Dietary/metabolism, Child, European Continental Ancestry Group, Female, Humans, Male, Obesity/metabolism",

author = "Hill, {Kathleen M.} and Braun, {Michelle M} and Egan, {Kara A.} and Martin, {Berdine R.} and McCabe, {Linda D.} and Munro Peacock and McCabe, {George P.} and Weaver, {Connie M.}",

year = "2011",

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doi = "10.1210/jc.2010-2709",

language = "English (US)",

volume = "96",

pages = "2171--2177",

journal = "The Journal of clinical endocrinology and metabolism",

issn = "0021-972X",

publisher = "The Endocrine Society",

number = "7",

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T1 - Obesity augments calcium-induced increases in skeletal calcium retention in adolescents

AU - Hill, Kathleen M.

AU - Braun, Michelle M

AU - Egan, Kara A.

AU - Martin, Berdine R.

AU - McCabe, Linda D.

AU - Peacock, Munro

AU - McCabe, George P.

AU - Weaver, Connie M.

PY - 2011/7

Y1 - 2011/7

N2 - CONTEXT: Overweight adolescents have low bone mineral content for weight and are at increased risk for fractures.OBJECTIVE: The aim was to determine whether overweight and obesity influence the positive relationship between dietary calcium intake and skeletal calcium retention in adolescents.DESIGN: Analysis of pooled data from calcium balance studies in adolescents.SETTING: Participants each underwent a 3-wk calcium balance study in a controlled environment.PARTICIPANTS: Participants included 280 White, Black, and Asian boys (n = 73) and girls (n = 207) ages 10-16 yr.MAIN OUTCOME MEASURE: The relationship among body mass index (BMI), calcium intake, and calcium retention was modeled using linear regression.RESULTS: Calcium intake, BMI, sex, race, and age explained 27.9% of the variation in calcium retention. At low calcium intakes, there was no effect of BMI on skeletal calcium retention, but at higher calcium intakes, BMI increased skeletal calcium retention.CONCLUSIONS: Greater gains in calcium retention occur with increases in calcium intake in adolescents with higher BMI compared with those with lower BMI. Additional studies are needed to investigate whether increasing calcium intake reduces the increased risk of fracture associated with overweight and obesity in adolescents.

AB - CONTEXT: Overweight adolescents have low bone mineral content for weight and are at increased risk for fractures.OBJECTIVE: The aim was to determine whether overweight and obesity influence the positive relationship between dietary calcium intake and skeletal calcium retention in adolescents.DESIGN: Analysis of pooled data from calcium balance studies in adolescents.SETTING: Participants each underwent a 3-wk calcium balance study in a controlled environment.PARTICIPANTS: Participants included 280 White, Black, and Asian boys (n = 73) and girls (n = 207) ages 10-16 yr.MAIN OUTCOME MEASURE: The relationship among body mass index (BMI), calcium intake, and calcium retention was modeled using linear regression.RESULTS: Calcium intake, BMI, sex, race, and age explained 27.9% of the variation in calcium retention. At low calcium intakes, there was no effect of BMI on skeletal calcium retention, but at higher calcium intakes, BMI increased skeletal calcium retention.CONCLUSIONS: Greater gains in calcium retention occur with increases in calcium intake in adolescents with higher BMI compared with those with lower BMI. Additional studies are needed to investigate whether increasing calcium intake reduces the increased risk of fracture associated with overweight and obesity in adolescents.

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KW - Child

KW - European Continental Ancestry Group

KW - Female

KW - Humans

KW - Male

KW - Obesity/metabolism

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Obesity augments calcium-induced increases in skeletal calcium retention in adolescents

Abstract

Keywords

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