TY - JOUR
T1 - Oral administration of marine collagen peptides prepared from chum salmon (Oncorhynchus keta) improves wound healing following cesarean section in rats
AU - Wang, Junbo
AU - Xu, Meihong
AU - Liang, Rui
AU - Zhao, Ming
AU - Zhang, Zhaofeng
AU - Li, Yong
N1 - Publisher Copyright:
© 2015 Junbo Wang et al.
PY - 2015/5/13
Y1 - 2015/5/13
N2 - Background: The goal of the present study was to investigate the wound-healing potential of marine collagen peptides (MCPs) from chum salmon skin administered to rats following cesarean section (CS). Methods: Ninety-six pregnant Sprague-Dawley rats were randomly divided into four groups: a vehicle group and three MCP groups. After CS, rats were intragastrically given MCPs at doses of 0, 0.13, 0.38, 1.15 g/kg∗bw, respectively. On postoperative days 7, 14, and 21, the uterine bursting pressure, skin tensile strength, hydroxyproline (Hyp) concentrations, and histological and immunohistochemical characteristics of the scar tissue were examined. Results: In the MCP groups, the skin tensile strength, uterine bursting pressure, and Hyp were significantly higher than those in the vehicle group at all three time points (p<0.05). The formation of capillary, fibroblast, and collagen fiber, the expression of platelet-endothelial cell adhesion molecule-1, basic fibroblast growth factor, and transforming growth factor beta-1 were increased in the MCP groups (p<0.05). Conclusion: MCPs could accelerate the process of wounding healing in rats after CS.
AB - Background: The goal of the present study was to investigate the wound-healing potential of marine collagen peptides (MCPs) from chum salmon skin administered to rats following cesarean section (CS). Methods: Ninety-six pregnant Sprague-Dawley rats were randomly divided into four groups: a vehicle group and three MCP groups. After CS, rats were intragastrically given MCPs at doses of 0, 0.13, 0.38, 1.15 g/kg∗bw, respectively. On postoperative days 7, 14, and 21, the uterine bursting pressure, skin tensile strength, hydroxyproline (Hyp) concentrations, and histological and immunohistochemical characteristics of the scar tissue were examined. Results: In the MCP groups, the skin tensile strength, uterine bursting pressure, and Hyp were significantly higher than those in the vehicle group at all three time points (p<0.05). The formation of capillary, fibroblast, and collagen fiber, the expression of platelet-endothelial cell adhesion molecule-1, basic fibroblast growth factor, and transforming growth factor beta-1 were increased in the MCP groups (p<0.05). Conclusion: MCPs could accelerate the process of wounding healing in rats after CS.
KW - Basic fibroblast growth factor
KW - CD31
KW - Cesarean section
KW - Marine collagen peptide
KW - Transforming growth factor beta 1
KW - Wound healing
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U2 - 10.3402/fnr.v59.26411
DO - 10.3402/fnr.v59.26411
M3 - Article
AN - SCOPUS:84929493003
SN - 1654-6628
VL - 59
JO - Food and Nutrition Research
JF - Food and Nutrition Research
M1 - 26411
ER -