Oral administration of marine collagen peptides prepared from chum salmon (Oncorhynchus keta) improves wound healing following cesarean section in rats

Junbo Wang, Meihong Xu, Rui Liang, Ming Zhao, Zhaofeng Zhang, Yong Li

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Background: The goal of the present study was to investigate the wound-healing potential of marine collagen peptides (MCPs) from chum salmon skin administered to rats following cesarean section (CS). Methods: Ninety-six pregnant Sprague-Dawley rats were randomly divided into four groups: a vehicle group and three MCP groups. After CS, rats were intragastrically given MCPs at doses of 0, 0.13, 0.38, 1.15 g/kg∗bw, respectively. On postoperative days 7, 14, and 21, the uterine bursting pressure, skin tensile strength, hydroxyproline (Hyp) concentrations, and histological and immunohistochemical characteristics of the scar tissue were examined. Results: In the MCP groups, the skin tensile strength, uterine bursting pressure, and Hyp were significantly higher than those in the vehicle group at all three time points (p<0.05). The formation of capillary, fibroblast, and collagen fiber, the expression of platelet-endothelial cell adhesion molecule-1, basic fibroblast growth factor, and transforming growth factor beta-1 were increased in the MCP groups (p<0.05). Conclusion: MCPs could accelerate the process of wounding healing in rats after CS.

Original languageEnglish (US)
Article number26411
JournalFood and Nutrition Research
Volume59
DOIs
StatePublished - May 13 2015

Bibliographical note

Publisher Copyright:
© 2015 Junbo Wang et al.

Keywords

  • Basic fibroblast growth factor
  • CD31
  • Cesarean section
  • Marine collagen peptide
  • Transforming growth factor beta 1
  • Wound healing

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