Osteointegration of implants in radiated bone with and without adjunctive hyperbaric oxygen

Peter E. Larsen, Michael J. Stronczek, F. Michael Beck, Michael Rohrer

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

A study was undertaken to evaluate the integration of endosseous implants in rabbit tibias that had received a tumorocidal dose of radiation. The effect of hyperbaric oxygen on integration in this compromised situation was also evaluated. Despite clinical and radiographic evidence of success of all implants, there was a significant decrease in amount of histologic bony integration of implants placed in the tibias that had received radiation therapy when compared to contralateral control implants. Adjunctive hyperbaric oxygen therapy significantly improved the amount of histologic integration of implants placed within the radiated tibias evaluated at 10 and 16 weeks after placement. Hyperbaric oxygen was also associated with better soft tissue wound healing in the radiated surgical site. Increased integration time significantly improved the amount of histologic integration in the animals that did not receive hyperbaric oxygen.

Original languageEnglish (US)
Pages (from-to)280-287
Number of pages8
JournalJournal of Oral and Maxillofacial Surgery
Volume51
Issue number3
DOIs
StatePublished - 1993

Bibliographical note

Funding Information:
I would like to out the project, and Carole W. Myer, DVM, for her help in the development of was funded by Calcitek Inc and the Ohio State Dentistry. ternational.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

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