TY - JOUR
T1 - Outcome and prognostic indicators in cats undergoing splenectomy for splenic mast cell tumors
AU - Kraus, Kelly A.
AU - Clifford, Craig A.
AU - Davis, Garrett J.
AU - Kiefer, Kristina M.
AU - Drobatz, Kenneth J.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - This was a multi-institutional retrospective study evaluating the outcome and clinical parameters associated with the postoperative prognosis of 36 cats with splenic mast cell tumors treated with splenectomy. Clinical parameters reviewed included signalment, clinical history, results of staging tests, surgical variables, administration of blood products, presence of metastasis, postoperative complications, administration of chemotherapy postoperatively, chemotherapy protocol, and response to chemotherapy. Overall median survival time was 390 days (range, 2-1737 days). Administration of a blood product (P <.0001), metastasis to a regional lymph node (P =.022), and evidence of either concurrent or historical neoplasia (P =.037) were negatively associated with survival. Response to chemotherapy (P =.0008) was associated with an improved median survival time. Larger-scale prospective studies evaluating different chemotherapy protocols are required to elucidate the discrepancy between lack of survival benefit with administration of chemotherapy and improvement in survival time with positive response to chemotherapy.
AB - This was a multi-institutional retrospective study evaluating the outcome and clinical parameters associated with the postoperative prognosis of 36 cats with splenic mast cell tumors treated with splenectomy. Clinical parameters reviewed included signalment, clinical history, results of staging tests, surgical variables, administration of blood products, presence of metastasis, postoperative complications, administration of chemotherapy postoperatively, chemotherapy protocol, and response to chemotherapy. Overall median survival time was 390 days (range, 2-1737 days). Administration of a blood product (P <.0001), metastasis to a regional lymph node (P =.022), and evidence of either concurrent or historical neoplasia (P =.037) were negatively associated with survival. Response to chemotherapy (P =.0008) was associated with an improved median survival time. Larger-scale prospective studies evaluating different chemotherapy protocols are required to elucidate the discrepancy between lack of survival benefit with administration of chemotherapy and improvement in survival time with positive response to chemotherapy.
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U2 - 10.5326/JAAHA-MS-6280
DO - 10.5326/JAAHA-MS-6280
M3 - Article
C2 - 26083443
AN - SCOPUS:84942921571
SN - 0587-2871
VL - 51
SP - 231
EP - 238
JO - Journal of the American Animal Hospital Association
JF - Journal of the American Animal Hospital Association
IS - 4
ER -