Pancreatic Islet Cell Carcinoma With Gastrin and Vasoactive Intestinal Polypeptide Production

Thomas P. Barragry; Mark R. Wick; John P Delaney

doi:10.1001/archsurg.1985.01390340074015

Pancreatic Islet Cell Carcinoma With Gastrin and Vasoactive Intestinal Polypeptide Production

Thomas P. Barragry, Mark R. Wick, John P Delaney

Surgery

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

• The case history of a patient with an islet cell carcinoma, which produced both gastrin and vasoactive intestinal polypeptide (VIP), is presented. Although several examples have been observed of the combined production of these hormones by pancreatic endocrine tumors, few reports have related the clinical details of such cases. Resolution of diarrhea occurred in our patient after institution of nasogastric suction and cimetidine therapy, suggesting that gastric hypersecretion, rather than VIP activity, accounted for this problem. Chemotherapy with streptozotocin and 5-fluorouracil was highly effective in ameliorating clinical symptoms, diminishing serum levels of gastrin and VIP, and greatly reducing the bulk of metastatic disease in this case.

Original language	English (US)
Pages (from-to)	1178-1181
Number of pages	4
Journal	Archives of Surgery
Volume	120
Issue number	10
DOIs	https://doi.org/10.1001/archsurg.1985.01390340074015
State	Published - Oct 1985

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1001/archsurg.1985.01390340074015

OpenUrl availability

Full text

Cite this

@article{563db1d810404037a4f62b333111cc96,

title = "Pancreatic Islet Cell Carcinoma With Gastrin and Vasoactive Intestinal Polypeptide Production",

abstract = "• The case history of a patient with an islet cell carcinoma, which produced both gastrin and vasoactive intestinal polypeptide (VIP), is presented. Although several examples have been observed of the combined production of these hormones by pancreatic endocrine tumors, few reports have related the clinical details of such cases. Resolution of diarrhea occurred in our patient after institution of nasogastric suction and cimetidine therapy, suggesting that gastric hypersecretion, rather than VIP activity, accounted for this problem. Chemotherapy with streptozotocin and 5-fluorouracil was highly effective in ameliorating clinical symptoms, diminishing serum levels of gastrin and VIP, and greatly reducing the bulk of metastatic disease in this case.",

author = "Barragry, {Thomas P.} and Wick, {Mark R.} and Delaney, {John P}",

year = "1985",

month = oct,

doi = "10.1001/archsurg.1985.01390340074015",

language = "English (US)",

volume = "120",

pages = "1178--1181",

journal = "Archives of Surgery",

issn = "0004-0010",

publisher = "American Medical Association",

number = "10",

}

TY - JOUR

T1 - Pancreatic Islet Cell Carcinoma With Gastrin and Vasoactive Intestinal Polypeptide Production

AU - Barragry, Thomas P.

AU - Wick, Mark R.

AU - Delaney, John P

PY - 1985/10

Y1 - 1985/10

N2 - • The case history of a patient with an islet cell carcinoma, which produced both gastrin and vasoactive intestinal polypeptide (VIP), is presented. Although several examples have been observed of the combined production of these hormones by pancreatic endocrine tumors, few reports have related the clinical details of such cases. Resolution of diarrhea occurred in our patient after institution of nasogastric suction and cimetidine therapy, suggesting that gastric hypersecretion, rather than VIP activity, accounted for this problem. Chemotherapy with streptozotocin and 5-fluorouracil was highly effective in ameliorating clinical symptoms, diminishing serum levels of gastrin and VIP, and greatly reducing the bulk of metastatic disease in this case.

AB - • The case history of a patient with an islet cell carcinoma, which produced both gastrin and vasoactive intestinal polypeptide (VIP), is presented. Although several examples have been observed of the combined production of these hormones by pancreatic endocrine tumors, few reports have related the clinical details of such cases. Resolution of diarrhea occurred in our patient after institution of nasogastric suction and cimetidine therapy, suggesting that gastric hypersecretion, rather than VIP activity, accounted for this problem. Chemotherapy with streptozotocin and 5-fluorouracil was highly effective in ameliorating clinical symptoms, diminishing serum levels of gastrin and VIP, and greatly reducing the bulk of metastatic disease in this case.

UR - http://www.scopus.com/inward/record.url?scp=0022372484&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022372484&partnerID=8YFLogxK

U2 - 10.1001/archsurg.1985.01390340074015

DO - 10.1001/archsurg.1985.01390340074015

M3 - Article

C2 - 2994597

AN - SCOPUS:0022372484

SN - 0004-0010

VL - 120

SP - 1178

EP - 1181

JO - Archives of Surgery

JF - Archives of Surgery

IS - 10

ER -

Pancreatic Islet Cell Carcinoma With Gastrin and Vasoactive Intestinal Polypeptide Production

Abstract

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this