Peptide inhibitor of morphine- and β-endorphin-induced analgesia

N. M. Lee, H. J. Friedman, L. Leybin, T. M. Cho, H. H. Loh, C. H. Li

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The synthetic β-endorphine analogs with the omission of the NH2-terminal [Met]enkephalin segment [β-endorphin-(6-31) and β-endorphin-(20-31)] are shown to inhibit morphine- or β-endorphin-induced analgesia in mice by the tail-flick test, whereas the synthetic NH2-terminal pentadecapeptide β-endorphin-(1-15) has no inhibitory activity. This study raises the possibility that endogenous inhibiting peptides exist in the brain which play a role in the regulation of endorphin actions.

Original languageEnglish (US)
Pages (from-to)5525-5526
Number of pages2
JournalUnknown Journal
Volume77
Issue number9 II
DOIs
StatePublished - 1980

Fingerprint Dive into the research topics of 'Peptide inhibitor of morphine- and β-endorphin-induced analgesia'. Together they form a unique fingerprint.

Cite this