Perinatal complications and genetic loading in schizophrenia: Preliminary findings

Steven B. Schwarzkopf; Henry A. Nasrallah; Stephen C. Olson; Jeffrey A. Coffman; Judy A. McLaughlin

doi:10.1016/0165-1781(89)90139-X

Perinatal complications and genetic loading in schizophrenia: Preliminary findings

Steven B. Schwarzkopf, Henry A. Nasrallah, Stephen C. Olson, Jeffrey A. Coffman, Judy A. McLaughlin

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Abstract

History of perinatal complications (PCs) and first degree family history (FH) of psychiatric illness were examined in groups of schizophrenic/ schizoaffective (n = 21) and bipolar (n = 10) patients. PCs were significantly more frequent in the schizophrenic and schizoaffective patients than in bipolar patients. An inverse relationship was found between PCs and FH status, with FH-positive patients having significantly fewer PCs than the FH-negative group. This relationship persisted when the bipolar patients were excluded. Findings emphasize the etiological importance of genetics and perinatal events in the psychoses, and support the validity of a familial/sporadic distinction.

Original language	English (US)
Pages (from-to)	233-239
Number of pages	7
Journal	Psychiatry Research
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/0165-1781(89)90139-X
State	Published - Mar 1989
Externally published	Yes

Keywords

Schizophrenia
bipolar
family history
perinatal complications

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AU - Olson, Stephen C.

AU - Coffman, Jeffrey A.

AU - McLaughlin, Judy A.

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Perinatal complications and genetic loading in schizophrenia: Preliminary findings

Abstract

Keywords

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