TY - JOUR
T1 - Peripheral Quantitative Computed Tomography
T2 - Measurement Sensitivity in Persons With and Without Spinal Cord Injury
AU - Shields, Richard K.
AU - Dudley-Javoroski, Shauna
AU - Boaldin, Kathryn M.
AU - Corey, Trent A.
AU - Fog, Daniel B.
AU - Ruen, Jacquelyn M.
PY - 2006/10
Y1 - 2006/10
N2 - Shields RK, Dudley-Javoroski S, Boaldin KM, Corey TA, Fog DB, Ruen JM. Peripheral quantitative computed tomography: measurement sensitivity in persons with and without spinal cord injury. Objectives: To determine (1) the error attributable to external tibia-length measurements by using peripheral quantitative computed tomography (pQCT) and (2) the effect these errors have on scan location and tibia trabecular bone mineral density (BMD) after spinal cord injury (SCI). Design: Blinded comparison and criterion standard in matched cohorts. Setting: Primary care university hospital. Participants: Eight able-bodied subjects underwent tibia length measurement. A separate cohort of 7 men with SCI and 7 able-bodied age-matched male controls underwent pQCT analysis. Interventions: Not applicable. Main Outcome Measures: The projected worst-case tibia-length-measurement error translated into a pQCT slice placement error of ±3mm. We collected pQCT slices at the distal 4% tibia site, 3mm proximal and 3mm distal to that site, and then quantified BMD error attributable to slice placement. Results: Absolute BMD error was greater for able-bodied than for SCI subjects (5.87mg/cm3 vs 4.5mg/cm3). However, the percentage error in BMD was larger for SCI than able-bodied subjects (4.56% vs 2.23%). Conclusions: During cross-sectional studies of various populations, BMD differences up to 5% may be attributable to variation in limb-length-measurement error.
AB - Shields RK, Dudley-Javoroski S, Boaldin KM, Corey TA, Fog DB, Ruen JM. Peripheral quantitative computed tomography: measurement sensitivity in persons with and without spinal cord injury. Objectives: To determine (1) the error attributable to external tibia-length measurements by using peripheral quantitative computed tomography (pQCT) and (2) the effect these errors have on scan location and tibia trabecular bone mineral density (BMD) after spinal cord injury (SCI). Design: Blinded comparison and criterion standard in matched cohorts. Setting: Primary care university hospital. Participants: Eight able-bodied subjects underwent tibia length measurement. A separate cohort of 7 men with SCI and 7 able-bodied age-matched male controls underwent pQCT analysis. Interventions: Not applicable. Main Outcome Measures: The projected worst-case tibia-length-measurement error translated into a pQCT slice placement error of ±3mm. We collected pQCT slices at the distal 4% tibia site, 3mm proximal and 3mm distal to that site, and then quantified BMD error attributable to slice placement. Results: Absolute BMD error was greater for able-bodied than for SCI subjects (5.87mg/cm3 vs 4.5mg/cm3). However, the percentage error in BMD was larger for SCI than able-bodied subjects (4.56% vs 2.23%). Conclusions: During cross-sectional studies of various populations, BMD differences up to 5% may be attributable to variation in limb-length-measurement error.
KW - Bone density
KW - Osteoporosis
KW - Rehabilitation
KW - Spinal cord injuries
KW - Tibia
KW - Tomography, x-ray computed
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U2 - 10.1016/j.apmr.2006.07.257
DO - 10.1016/j.apmr.2006.07.257
M3 - Article
C2 - 17023249
AN - SCOPUS:33749135685
SN - 0003-9993
VL - 87
SP - 1376
EP - 1381
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
IS - 10
ER -