Pervasive cryptic epistasis in molecular evolution

Earth & Environmental Sciences

• epistasis 100%
• mutation 64%
• mutant 22%
• phylogenetics 17%
• amino acid 9%
• replacement 8%
• enzyme 8%
• transition 6%
• effect 5%
• analysis 2%

Medicine & Life Sciences

• Molecular Evolution 83%
• Oxidoreductases 59%
• Mutation 36%
• Escherichia coli 22%
• Pseudomonas aeruginosa 20%
• Catalytic Domain 9%
• Amino Acids 7%
• Enzymes 5%

Agriculture & Biology

• epistasis 77%
• mutation 44%
• Pseudomonas aeruginosa 21%
• Escherichia coli 20%
• phylogeny 12%
• active sites 10%
• amino acids 6%
• enzymes 4%