Pharmacological profile of a novel H2S-releasing aspirin

Anna Sparatore, Elena Perrino, Valerio Tazzari, Daniela Giustarini, Ranieri Rossi, Giuseppe Rossoni, Kati Erdman, Henning Schröder, Piero Del Soldato

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

The pharmacological profile of a new, safe, and effective hydrogen sulfide (H2S)-releasing derivative of aspirin (ACS14) is described. We report the synthesis of ACS14, and of its deacetylated metabolite (ACS21), the preliminary pharmacokinetics, and its in vivo metabolism, with the H2S plasma levels after intravenous administration in the rat. ACS14 maintains the thromboxane-suppressing activity of the parent compound, but seems to spare the gastric mucosa, by affecting redox imbalance through increased H2S/glutathione formation, heme oxygenase-1 promoter activity, and isoprostane suppression.

Original languageEnglish (US)
Pages (from-to)586-592
Number of pages7
JournalFree Radical Biology and Medicine
Volume46
Issue number5
DOIs
StatePublished - Mar 1 2009

Keywords

  • Aspirin
  • Dithiolethione
  • Free radicals
  • Glutathione
  • Heme oxygenase-1
  • Hydrogen sulfide
  • Thromboxane

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