Pharmacological profile of a novel H2S-releasing aspirin

Anna Sparatore; Elena Perrino; Valerio Tazzari; Daniela Giustarini; Ranieri Rossi; Giuseppe Rossoni; Kati Erdman; Henning Schröder; Piero Del Soldato

doi:10.1016/j.freeradbiomed.2008.11.013

Pharmacological profile of a novel H₂S-releasing aspirin

Anna Sparatore, Elena Perrino, Valerio Tazzari, Daniela Giustarini, Ranieri Rossi, Giuseppe Rossoni, Kati Erdman, Henning Schröder, Piero Del Soldato

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

The pharmacological profile of a new, safe, and effective hydrogen sulfide (H₂S)-releasing derivative of aspirin (ACS14) is described. We report the synthesis of ACS14, and of its deacetylated metabolite (ACS21), the preliminary pharmacokinetics, and its in vivo metabolism, with the H₂S plasma levels after intravenous administration in the rat. ACS14 maintains the thromboxane-suppressing activity of the parent compound, but seems to spare the gastric mucosa, by affecting redox imbalance through increased H₂S/glutathione formation, heme oxygenase-1 promoter activity, and isoprostane suppression.

Original language	English (US)
Pages (from-to)	586-592
Number of pages	7
Journal	Free Radical Biology and Medicine
Volume	46
Issue number	5
DOIs	https://doi.org/10.1016/j.freeradbiomed.2008.11.013
State	Published - Mar 1 2009

Keywords

Aspirin
Dithiolethione
Free radicals
Glutathione
Heme oxygenase-1
Hydrogen sulfide
Thromboxane

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10.1016/j.freeradbiomed.2008.11.013

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AU - Rossoni, Giuseppe

AU - Erdman, Kati

AU - Schröder, Henning

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