Pharmacology of highly selective, non-peptide delta opioid receptor antagonists

A. E. Takemori, M. Sofuoglu, M. Sultana, H. Nagase, P. S. Portoghese

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

Abstract

Naltrindole (NTI) and three of its analogues, N-Me-NTI, oxymorphindole (OMI), and the benzofuran analogue (NTB) were examined in the opioid receptor binding and antinociceptive assays and they were found to have a selectivity profile similar to that in smooth muscle assays, i.e. very selective for δ-opioid receptors.

Original languageEnglish (US)
Title of host publicationNew leads in opioid research
Subtitle of host publicationproceedings of the International Narcotics Research Conference. ICS914
EditorsJ.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
PublisherElsevier Science Publishers B.V.
Number of pages1
ISBN (Print)044481213X
StatePublished - Jan 1 1990
EventThe International Narcotics Research Conference -
Duration: Jul 8 1989Jul 13 1989

Publication series

NameNew leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914

Other

OtherThe International Narcotics Research Conference
Period7/8/897/13/89

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