Phobic anxiety in late-life in relationship to cognition and 5HTTLPR polymorphism

Susan K. Schultz, David J. Moser, Jeffrey R. Bishop, Vicki L. Ellingrod

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Anxiety in late-life may functionally impair the older adult. In this study the polymorphic region 5HTTLPR of the SLC6A4 gene was examined in relation to phobic anxiety and cognitive function. Sixty-four community-dwelling older adults were genotyped for the 5HTTLPR polymorphism to examine whether late-life phobias are associated with the short (s) allele and whether cognitive impairment may precipitate phobic behaviors in association with the s allele. Our findings suggested that phobic anxiety symptoms are significantly related to lower cognitive function. However, in this sample we did not detect a significant association between phobic anxiety and the 5HTTLPR genotype. The interaction between age-related changes in cognition and anxiety remain an important area for future studies.

Original languageEnglish (US)
Pages (from-to)305-306
Number of pages2
JournalPsychiatric Genetics
Issue number4
StatePublished - Dec 2005


  • Aging
  • Anxiety
  • Cognition

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