Phosphoramidate pronucleotides: A comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins

Medicine & Life Sciences

• phosphoramidic acid 100%
• Substrate Specificity 64%
• Histidine 64%
• tryptamine 50%
• Carrier Proteins 49%
• Nucleotides 46%
• Escherichia coli 40%
• Nucleosides 36%
• Amines 24%
• Adenosine 17%
• indole 15%
• nucleoside phosphotransferase 10%
• Enzymes 9%
• Fluorescence 9%
• Vidarabine 8%
• Adenosine Kinase 8%
• Guanosine 7%
• pyrimidine 7%
• Uridine 7%
• Hydrogen Bonding 6%
• Sulfur 6%
• purine 6%
• Adenosine Monophosphate 6%
• Tryptophan 6%
• Thymidine 5%
• Hydrolysis 5%
• Catalytic Domain 5%
• Kinetics 4%
• Oxygen 4%
• Anti-Bacterial Agents 3%
• Therapeutics 1%

Chemical Compounds

• Phosphoramidate 77%
• Histidine 55%
• Nucleotide 47%
• Tryptamine 44%
• Nucleoside 37%
• Adenosine 27%
• Protein 23%
• Kcat/Km 21%
• Amine 11%
• Indole 10%
• D-Tryptophan 9%
• L Isomer 8%
• Rate Constant 7%
• Phosphoryl 6%
• Uridine 6%
• Thymidine 6%
• Guanosine 6%
• Purine 5%
• Primary Amine 5%
• Pyrimidine 5%
• Chemical Element 4%
• Pharmacokinetics 4%
• Antimicrobial Agent 4%
• Hydrolysis 3%
• Fluorescence 3%
• Hydrogen 2%
• Dioxygen 2%