Phosphoribosylation of xanthine by extracts from insect cells

Mavis R. Swerdel, Ann Marie Fallon

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Using a sensitive TLC method, we have detected the production of xanthine monophosphate (XMP) from [14C]xanthine by mosquito cell extracts incubated in the presence of phosphoribosyl pyrophosphate and a phosphatase inhibitor. Extracts from both cultured Aedes albopictus cells, and from intact Aedes aegypti mosquitoes contained activity; particularly high activity was found in extracts from adult male mosquitoes. XMP-producing activity was at least 4-fold higher in extracts from cultured mosquito cells than in extracts from Drosophila melanogaster Kc cells or Spodoptera frugiperda (Lepidoptera) cells.

Original languageEnglish (US)
Pages (from-to)1181-1186
Number of pages6
JournalInsect Biochemistry
Issue number8
StatePublished - 1987


  • Aedes aegypti
  • Aedes albopictus
  • Cultured mosquito cells
  • xanthine
  • xanthine monophosphate

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