Abstract
Several laboratories have reported that dynorphin and vasopressin may be present in the same neurons and released together in a fixed ratio. In this study, we report that vasopressin and dynorphin can regulate morphine-induced analgesia in the mouse tail-flick test. Its action is opposite that observed for dynorphin because, when administered simultaneously with morphine, vasopressin in a dose-related manner potentiated morphine-induced analgesia while dynorphin antagonized it. When vasopressin and dynorphin is administered together with morphine, morphine ED50 returned to control level.
Original language | English (US) |
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Pages (from-to) | 317-319 |
Number of pages | 3 |
Journal | European Journal of Pharmacology |
Volume | 83 |
Issue number | 3-4 |
DOIs | |
State | Published - Sep 24 1982 |
Keywords
- Analgesia
- Dynorphin
- Morphine
- Vasopressin