Preventing and treating chronic disorders using the modified vaccination technique

Arpad Zsigmond Barabas, Donald Mackay Weir, Chad Douglas Cole, Arpad David Barabas, Nizar Jacques Bahlis, Richard Milton Graeff, Rene Lafreniere

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


It is anticipated that the ultimate solution for the prevention and termination of autoimmune disorders will be based on somehow manipulating the cells of the immune system to attain antigen (ag) specific downregulation and termination. In the last few years we have developed a new vaccination technique that we call "modified vaccination technique" (MVT). It has with equal effectiveness both prevented and terminated autoimmune disease causing events in an experimental autoimmune kidney disease model. We expect that our technique will be similarly applicable to the specific treatment and cure of numerous other chronic disorders presently treated only by drugs. The vaccine is composed of two components, an ag and a specific antibody against it. When these are combined at slight ag excess they constitute a vaccine which is capable of treating chronic ailments by redirecting immune response outcomes in the vaccinated host. Both components, like drugs, will have to be produced ex vivo in order to maintain uniformity, safety, efficacy, and specificity.

Original languageEnglish (US)
Pages (from-to)3892-3898
Number of pages7
JournalFrontiers in Bioscience
Issue number10
StatePublished - Jan 1 2009


  • Autoantibody
  • Autoantigen
  • Autoimmunity
  • Cancer
  • Immune complex
  • Modified vaccination technique
  • Review

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