A lack of knowledge about the correlates of maternal immunity required for protection of the placenta and fetus against congenital cytomegalovirus (CMV) transmission has complicated vaccine development. New work from Bialas and colleagues demonstrates a critical role for maternal CD4+ T cells in controlling viremia and preventing CMV-associated fetal disease.
Bibliographical noteFunding Information:
Support from National Institutes of Health grants HD082273, HD044864, HD079918, and AI114013 is acknowledged.
- Animal models
- Congenital cytomegalovirus infection
- Cytomegalovirus immunity
- Cytomegalovirus vaccine
- Pentameric complex