Priming within and across modalities: Exploring the nature of rCBF increases and decreases

Rajendra D. Badgaiyan, Daniel L. Schacter, Nathaniel M. Alpert

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Neuroimaging studies suggest that within-modality priming is associated with reduced regional cerebral blood flow (rCBF) in the extrastriate area, whereas cross-modality priming is associated with increased rCBF in prefrontal cortex. To characterize the nature of rCBF changes in within- and cross-modality priming, we conducted two neuroimaging experiments using positron emission tomography (PET). In experiment 1, rCBF changes in within-modality auditory priming on a word stem completion task were observed under same- and different-voice conditions. Both conditions were associated with decreased rCBF in extrastriate cortex. In the different-voice condition there were additional rCBF changes in the middle temporal gyrus and prefrontal cortex. Results suggest that the extrastriate involvement in within-modality priming is sensitive to a change in sensory modality of target stimuli between study and test, but not to a change in the feature of a stimulus within the same modality. In experiment 2, we studied cross-modality priming on a visual stem completion test after encoding under full- and divided-attention conditions. Increased rCBF in the anterior prefrontal cortex was observed in the full- but not in the divided-attention condition. Because explicit retrieval is compromised after encoding under the divided-attention condition, prefrontal involvement in cross-modality priming indicates recruitment of an aspect of explicit retrieval mechanism. The aspect of explicit retrieval that is most likely to be involved in cross-modality priming is the familiarity effect.

Original languageEnglish (US)
Pages (from-to)272-282
Number of pages11
Issue number2
StatePublished - 2001

Bibliographical note

Funding Information:
This research was supported by National Institutes of Health Grants MH57915 and MH60941 and Human Frontiers Science Program Grant RG0126.

Fingerprint Dive into the research topics of 'Priming within and across modalities: Exploring the nature of rCBF increases and decreases'. Together they form a unique fingerprint.

Cite this