TY - JOUR
T1 - Prognosis of possible reassortments in recent H5N2 epidemic influenza in USA
T2 - Implications for computer-assisted surveillance as well as drug/vaccine design
AU - Nandy, Ashesh
AU - Basak, Subhash C.
N1 - Publisher Copyright:
© 2015 Bentham Science Publishers.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - The recent H5N2 flu epidemic in US Midwest has led to deaths of millions of turkeys and farm bred poultry. While no human infections are reported to date, the rapid mutations in flu viruses can lead to more pathogenic subtypes. We have investigated such possibilities and have shown that H5N4, H5N9 and H5N6 are the most likely candidates for next round of viral reassortments, amongst which H5N9, if reassorted from Asiatic strains, could be highly pathogenic. We discuss here possibilities of anticipatory rational vaccine design based on work done earlier.
AB - The recent H5N2 flu epidemic in US Midwest has led to deaths of millions of turkeys and farm bred poultry. While no human infections are reported to date, the rapid mutations in flu viruses can lead to more pathogenic subtypes. We have investigated such possibilities and have shown that H5N4, H5N9 and H5N6 are the most likely candidates for next round of viral reassortments, amongst which H5N9, if reassorted from Asiatic strains, could be highly pathogenic. We discuss here possibilities of anticipatory rational vaccine design based on work done earlier.
KW - Graphical representation of RNA sequences
KW - H5N2 influenza
KW - HA-NA interdependence
KW - North American H5N2 epidemic
KW - Prognosis of flu reasortments
KW - Reassortments
UR - http://www.scopus.com/inward/record.url?scp=84942082152&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942082152&partnerID=8YFLogxK
U2 - 10.2174/1573409911666150722122034
DO - 10.2174/1573409911666150722122034
M3 - Article
C2 - 26202885
AN - SCOPUS:84942082152
SN - 1573-4099
VL - 11
SP - 110
EP - 116
JO - Current computer-aided drug design
JF - Current computer-aided drug design
IS - 2
ER -
