Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers

Amit Gangar; Adrian Fegan; Sidath C. Kumarapperuma; Carston R. Wagner

doi:10.1021/ja210894g

Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers

Amit Gangar, Adrian Fegan, Sidath C. Kumarapperuma, Carston R. Wagner

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Dihydrofolate reductase single-chain variable fragment (scFv) fusion proteins can be used for the targeted cellular delivery of oligonucleotides, conjugated small molecules, and proteins via labeling of oligonucleotides by bis-methotrexate.

Original language	English (US)
Pages (from-to)	2895-2897
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	134
Issue number	6
DOIs	https://doi.org/10.1021/ja210894g
State	Published - Feb 15 2012

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title = "Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers",

abstract = "Dihydrofolate reductase single-chain variable fragment (scFv) fusion proteins can be used for the targeted cellular delivery of oligonucleotides, conjugated small molecules, and proteins via labeling of oligonucleotides by bis-methotrexate.",

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AU - Gangar, Amit

AU - Fegan, Adrian

AU - Kumarapperuma, Sidath C.

AU - Wagner, Carston R.

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Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers

Abstract

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