Progress toward the treatment of arthritis by gene therapy

C. H. Evans, P. D. Robbins

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Gene therapy offers several novel advantages to the treatment of arthritis and other joint diseases. Therapeutic genes may be delivered locally to diseased joints or systemically to extra-articular locations using viral or non-viral vectors by ex vivo or in vivo strategies. Pre-clinical experiments with rabbits have demonstrated the utility of using a retrovirus to deliver the human interleukin-1 receptor antagonist to the synovial lining of joints. A human trial based on this principle has been approved by the Recombinant DNA Advisory Committee of NIH and should begin this year.

Original languageEnglish (US)
Pages (from-to)543-546
Number of pages4
JournalAnnals of Medicine
Issue number5
StatePublished - 1995
Externally publishedYes

Bibliographical note

Funding Information:
The authors’ work is this area is supported by NIH grant PO1 DK44935, Theragen Inc. and Orthogen GmbH. We thank Mrs Lou Duerring for typing the manuscript.

Copyright 2014 Elsevier B.V., All rights reserved.


  • Arthritis
  • Gene therapy
  • Interleukin-1 receptor antagonist
  • Synovium

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