Pseudodynamic combinatorial libraries: A receptor-assisted approach for drug discovery

Andrew D. Corbett; Jeremy D. Cheeseman; Romas J. Kazlauskas; James L. Gleason

doi:10.1002/anie.200453769

Pseudodynamic combinatorial libraries: A receptor-assisted approach for drug discovery

Andrew D. Corbett, Jeremy D. Cheeseman, Romas J. Kazlauskas, James L. Gleason

Synthetic Biology and Biotechnology Division

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Enzyme protection: An irreversible solid-phase, aqueous peptide coupling resulted in the formation of a library of eight dipeptides, while an irreversible protease-catalyzed hydrolysis destroyed them. Those dipeptides that bound to carbonic anhydrase were protected from destructions. Six cycles of active ester addition produced only the best-binding dipeptide (> 100:1) in 29% yield.

Original language	English (US)
Pages (from-to)	2432-2436
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	18
DOIs	https://doi.org/10.1002/anie.200453769
State	Published - Apr 26 2004

Keywords

Combinatorial chemistry
Drug design
Enzyme inhibitors
Kinetics
Receptors

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KW - Receptors

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Pseudodynamic combinatorial libraries: A receptor-assisted approach for drug discovery

Abstract

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