Abstract
We describe a 10-month-old, intact female American Cocker Spaniel with pulmonary lymphomatoid granulomatosis (PLG). On clinical examination, this dog presented with nonproductive dry cough, serous nasal discharge, dyspnea, and lack of appetite. Radiography showed a consolidated lesion in the left cranial lung lobe. Histopathologic examination showed a mixed population of atypical lymphoid cells that had infiltrated into the pulmonary blood vessels angiocentrically. The lymphocytes were CD3 positive, consistent with a pan-T-cell phenotype. The lymphoid cells in the lesion were also positive for CD20cy and CD79a, indicative of the presence of B cells. We also observed large Reed-Sternberg-like cells that were positive for CD15 and CD30, similar to observations in human pulmonary Hodgkin's disease (PHD). In conclusion, canine PLG in this Cocker Spaniel was associated with B and T cells, which is first identified in a case of canine PLG. It was histopathologically similar to human lymphomatoid granulomatosis and immunophenotypically similar to human PHD.
Original language | English (US) |
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Pages (from-to) | 921-923 |
Number of pages | 3 |
Journal | Veterinary pathology |
Volume | 44 |
Issue number | 6 |
DOIs | |
State | Published - Nov 2007 |
Bibliographical note
Funding Information:The study was supported by the Konkuk University Research Fund 2005. We thank Ms. R.-W. Jang for technical assistance. D.-N. Hwang and B.-T. Kang contributed to this paper as the co-first authors.
Keywords
- Dogs
- Immunohistochemistry
- Pulmonary Hodgkin's disease
- Pulmonary lymphomatoid granulomatosis