Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N′-nitrosonornicotine

Medicine & Life Sciences

• N'-nitrosonornicotine 100%
• DNA Adducts 70%
• Nasal Mucosa 65%
• Mouth Mucosa 61%
• Respiratory Mucosa 30%
• Olfactory Mucosa 18%
• Smokeless Tobacco 12%
• Nose 11%
• Hydroxylation 10%
• O2-(4-(3-pyridyl)-4-oxobut-1-yl)thymidine 10%
• 4-hydroxy-1-(3-pyridyl)-1-butanone 9%
• Carcinogens 9%
• Tobacco Products 8%
• Deoxyguanosine 6%
• Electrospray Ionization Mass Spectrometry 6%
• Cytosine 5%
• Guanine 5%
• Inbred F344 Rats 5%
• DNA 5%
• Tandem Mass Spectrometry 5%
• Mouth Neoplasms 5%
• Liquid Chromatography 4%
• Esophageal Neoplasms 4%
• Drinking Water 4%
• Cytochrome P-450 Enzyme System 4%
• Esophagus 4%
• Mouth 4%
• Smokers 3%
• Carcinogenesis 3%
• Lung 2%
• In Vitro Techniques 2%
• Therapeutics 1%

Chemical Compounds

• Nasal 74%
• Enantiomer 44%
• Adduct 40%
• Pharmacological Metabolism 8%
• Thymidine 6%
• Time 6%
• Cytosine 6%
• Drinking Water 5%
• Guanine 5%
• Stereoselectivity 5%
• Cytochrome 4%
• Mass Spectrometry 3%
• Liquid 3%