TY - JOUR
T1 - Quantitative 31P spectroscopic imaging of human brain at 4 Tesla
T2 - Assessment of gray and white matter differences of phosphocreatine and ATP
AU - Hetherington, H. P.
AU - Spencer, D. D.
AU - Vaughan, J. T.
AU - Pan, J. W.
PY - 2001/1/20
Y1 - 2001/1/20
N2 - This report describes the implementation and application of a multicompartment analysis of 31P spectroscopic imaging data to determine the tissue-specific heterogeneities in metabolite content in the human brain and surrounding tissue. Using this information and a multicompartment regression analysis the phosphocreatine and ATP content of "pure" cerebral gray and white matter, the cerebellum, and skeletal muscle was determined in a group of 10 healthy volunteers. The data were converted to mM units using previously reported values for the T1s of phosphocreatine and ATP at 4 T, the water content of human brain, and an external reference for absolute quantification. The phosphocreatine concentration in cerebral gray and white matter, the cerebellum, and skeletal muscle was 3.53 ± 0.33, 3.33 ± 0.37, 3.75 ± 0.66, and 25.8 ± 2.3 mM, respectively. The ATP concentration in cerebral gray and white matter, the cerebellum, and skeletal muscle was 2.19 ± 0.33, 3.41 ± 0.33, 1.75 ± 0.58, and 8.5 ± 1.9 mM, respectively.
AB - This report describes the implementation and application of a multicompartment analysis of 31P spectroscopic imaging data to determine the tissue-specific heterogeneities in metabolite content in the human brain and surrounding tissue. Using this information and a multicompartment regression analysis the phosphocreatine and ATP content of "pure" cerebral gray and white matter, the cerebellum, and skeletal muscle was determined in a group of 10 healthy volunteers. The data were converted to mM units using previously reported values for the T1s of phosphocreatine and ATP at 4 T, the water content of human brain, and an external reference for absolute quantification. The phosphocreatine concentration in cerebral gray and white matter, the cerebellum, and skeletal muscle was 3.53 ± 0.33, 3.33 ± 0.37, 3.75 ± 0.66, and 25.8 ± 2.3 mM, respectively. The ATP concentration in cerebral gray and white matter, the cerebellum, and skeletal muscle was 2.19 ± 0.33, 3.41 ± 0.33, 1.75 ± 0.58, and 8.5 ± 1.9 mM, respectively.
KW - Brain
KW - P
KW - Quantification
KW - Spectroscopic imaging
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U2 - 10.1002/1522-2594(200101)45:1<46::AID-MRM1008>3.0.CO;2-N
DO - 10.1002/1522-2594(200101)45:1<46::AID-MRM1008>3.0.CO;2-N
M3 - Article
C2 - 11146485
AN - SCOPUS:0035163231
SN - 0740-3194
VL - 45
SP - 46
EP - 52
JO - Magnetic resonance in medicine
JF - Magnetic resonance in medicine
IS - 1
ER -