TY - JOUR
T1 - Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy
AU - Lucisano, Marília Pacífico
AU - Nelson-Filho, Paulo
AU - Morse, Leslie
AU - Battaglino, Ricardo
AU - Watanabe, Plauto Christopher Aranha
AU - da Silva, Raquel Assed Bezerra
AU - da Silva, Lea Assed Bezerra
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Precise techniques for the measurement of maxillary bone mineral density (BMD) are useful for the early diagnosis of systemic diseases. The aim of this study was to compare in vivo the efficacy of dualenergy x-ray absorptiometry (DXA) and radiographic densitometry for the measurement of BMD after systemic administration of sodium alendronate. Wistar rats were randomly allocated to a control group (n = 5), which received distilled water, and a sodium alendronate group (n = 8), which received two doses of chemically pure sodium alendronate (1 mg/ kg) per week. After 8 weeks, the animals were euthanized, the tibias were removed, and the BMD of the proximal tibial metaphysis was analyzed radiographically and by DXA. The data were subjected to statistical analysis by the Kruskal-Wallis test at a significance level of 5%. Both of the techniques revealed that the alendronate-treated group had a significantly higher BMD (p < 0.05) than the control group after 8 weeks of treatment. Comparing the groups with and without alendronate therapy revealed increases of 14.9% and 29.6% in BMD, as detected radiographically and by DXA, respectively. In conclusion, both of the methods were able to detect an increase in BMD of the proximal tibial metaphysis after alendronate therapy.
AB - Precise techniques for the measurement of maxillary bone mineral density (BMD) are useful for the early diagnosis of systemic diseases. The aim of this study was to compare in vivo the efficacy of dualenergy x-ray absorptiometry (DXA) and radiographic densitometry for the measurement of BMD after systemic administration of sodium alendronate. Wistar rats were randomly allocated to a control group (n = 5), which received distilled water, and a sodium alendronate group (n = 8), which received two doses of chemically pure sodium alendronate (1 mg/ kg) per week. After 8 weeks, the animals were euthanized, the tibias were removed, and the BMD of the proximal tibial metaphysis was analyzed radiographically and by DXA. The data were subjected to statistical analysis by the Kruskal-Wallis test at a significance level of 5%. Both of the techniques revealed that the alendronate-treated group had a significantly higher BMD (p < 0.05) than the control group after 8 weeks of treatment. Comparing the groups with and without alendronate therapy revealed increases of 14.9% and 29.6% in BMD, as detected radiographically and by DXA, respectively. In conclusion, both of the methods were able to detect an increase in BMD of the proximal tibial metaphysis after alendronate therapy.
KW - Alendronate
KW - Bone density
KW - Bone remodeling
UR - http://www.scopus.com/inward/record.url?scp=84880591724&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880591724&partnerID=8YFLogxK
U2 - 10.1590/S1806-83242013000300005
DO - 10.1590/S1806-83242013000300005
M3 - Article
C2 - 23739782
AN - SCOPUS:84880591724
SN - 1806-8324
VL - 27
SP - 252
EP - 257
JO - Brazilian Oral Research
JF - Brazilian Oral Research
IS - 3
ER -