Recognition memory for faces in schizophrenia patients and their first-degree relatives

Heather M. Conklin; Monica E. Calkins; Charles W. Anderson; Thomas J. Dinzeo; William G. Iacono

doi:10.1016/S0028-3932(02)00091-X

Recognition memory for faces in schizophrenia patients and their first-degree relatives

Heather M. Conklin, Monica E. Calkins, Charles W. Anderson, Thomas J. Dinzeo, William G. Iacono

Psychology (Twin Cities)

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

It has consistently been shown that schizophrenia patients are impaired in recognition memory for faces. However, studies have not examined the specificity of this deficit relative to other cognitive functions nor the relationship between this deficit and particular schizophrenia symptoms. In addition, no studies have examined recognition memory for faces in unaffected biological relatives of schizophrenia patients who likely share some of the genetic diathesis for this disorder without presenting the potential confounds of mentally ill study samples. The Faces subtests from the Wechsler Memory Scale - Third Edition were used to evaluate recognition memory for faces in 39 schizophrenia patients, 33 of their first-degree relatives and 56 normal controls. Both schizophrenia patients and their relatives were impaired, relative to control participants, in recognition memory for faces after partialing out group differences in spatial attention or verbal memory. Further, recognition memory for faces was associated with positive symptoms in the schizophrenia group and schizotypal personality traits in the relative group. These findings may have important implications for reducing etiological heterogeneity among schizophrenia populations, identifying disorder susceptibility among their relatives and furthering understanding of disorder etiology.

Original language	English (US)
Pages (from-to)	2314-2324
Number of pages	11
Journal	Neuropsychologia
Volume	40
Issue number	13
DOIs	https://doi.org/10.1016/S0028-3932(02)00091-X
State	Published - 2002

Bibliographical note

Funding Information:
This work was supported by grants from the National Institute of Mental Health (MH 49738 and MH 17069). Portions of this paper were presented at the Biennial meeting of the International Congress on Schizophrenia Research, May 2001, Whistler, BC, and also at Behavior Genetic Principles—Development, Personality, and Psychopathology: A Festschrift in Honor of Prof. Irving I. Gottesman, 8–9 June 2001, Minneapolis, MN. We thank the participants of this study for their time and effort, and Clayton E. Curtis, William M. Grove, Joshua Brosz, Joanna Fiszdon, Amy Hallberg, David Lake, Craig Moen, and Janay Nordby for their contributions to the Research in Schizophrenia (RISC) project from which the data for this paper were obtained.

Keywords

Diathesis
Etiology
Genetic vulnerability
Schizotypy
Wechsler Memory Scale

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abstract = "It has consistently been shown that schizophrenia patients are impaired in recognition memory for faces. However, studies have not examined the specificity of this deficit relative to other cognitive functions nor the relationship between this deficit and particular schizophrenia symptoms. In addition, no studies have examined recognition memory for faces in unaffected biological relatives of schizophrenia patients who likely share some of the genetic diathesis for this disorder without presenting the potential confounds of mentally ill study samples. The Faces subtests from the Wechsler Memory Scale - Third Edition were used to evaluate recognition memory for faces in 39 schizophrenia patients, 33 of their first-degree relatives and 56 normal controls. Both schizophrenia patients and their relatives were impaired, relative to control participants, in recognition memory for faces after partialing out group differences in spatial attention or verbal memory. Further, recognition memory for faces was associated with positive symptoms in the schizophrenia group and schizotypal personality traits in the relative group. These findings may have important implications for reducing etiological heterogeneity among schizophrenia populations, identifying disorder susceptibility among their relatives and furthering understanding of disorder etiology.",

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Recognition memory for faces in schizophrenia patients and their first-degree relatives

Abstract

Bibliographical note

Keywords

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