The field of myocardial regeneration (angiogenesis and myogenesis) might prove to play an important role in the future management of cardiovascular disease. Stem cells are currently undergoing testing in Phase I and Phase II clinical trials. Methods of delivery will affect the outcome of such therapies, perhaps significantly. This document provides suggested guidance in 4 methods of delivery: endocardial, intracoronary, coronary sinus, and epicardial.
Bibliographical noteFunding Information:
Dr. Dib has received research grants from Cardiovascular Biotherapeutics and Angioblast Systems, Inc. ; and consultant fees from Biologics Delivery Systems, Inc. (Cordis Corporation), and Cardio3 Biosciences. Dr. Bartunek has received research grants from Cardio3 Biosciences . Dr. Zeiher is an advisor and co-founder of t2Cure. Dr. Peters has received research grants from CardioPolymers Inc. and Medtronic, Inc. ; is a consultant and honorarium recipient from CardioPolymers Inc., Ablation Frontiers Inc., AstraZeneca Inc., Sanofi Aventis Inc., Magnetecs Inc., Bard Inc., and Bioheart Inc.; and has intellectual property and stock in CardioPolymers Inc. Dr. Sanborn is on the Speakers' Bureau of Merck; and is a Chairman and on the Data Safety Monitoring Board of St. Jude Medical. Dr. DeMaria has received research grants from Lantheus , Acusphere , CV Therapeutics , Cardiovascular Biotherapeutics , Angioblast Systems, Inc. , Philips Medical Systems , and General Electric Medical Systems ; and has stock options in Cardionet. Dr. Schatz has a licensing agreement with Biologics Delivery Systems and Cordis Corporation; is on the Scientific Advisory Board and Data Safety Monitoring Board of Baxter; and is a Speaker for Cordis Corporation and Medtronic, Inc. Dr. Itescu is President and founder of Angioblast Systems, Inc. Dr. Miller has received a research grant from Thoratec Corp . Dr. Dangas is a consultant for and has received honoraria from Cordis Corporation; and is a speaker for Cordis Corporation, Medtronic, Inc, and Boston Scientific. Dr. Popma has received research grants from Abbott Vascular , Boston Scientific , Cordis , ev3 , and Medtronic, Inc. Dr. Hall is a consultant for Catholic Healthcare West; and has received grants NIH - R01HL081715A1 and NIH - 1R21DK078029-01 .
- myocardial regeneration
- stem cells