Red blood cell aggregation quantitated via Myrenne aggregometer and yield shear stress

Byoung Kwon Lee, Tamas Alexy, Rosalinda B. Wenby, Herbert J. Meiselman

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Although the study of red blood cell (RBC) aggregation continues to be of basic science and clinical interest, aggregation standards for calibration do not exist, and most aggregation studies report data in terms of arbitrary units: quantitative comparisons between studies are thus essentially precluded. However, use of low shear viscometry plus the Casson equation provides a yield shear stress that has defined units and is known to reflect RBC aggregation. Employing human RBC-plasma suspensions exhibiting a wide range of aggregation, the present study examined relations between yield shear stress values and aggregation indices obtained using the Myrenne aggregometer: the latter approach uses a light-transmission technique and provides an "M" index at stasis and an "M1" at very low shear. Our results for normal controls and for angina patients without coronary artery disease indicate highly significant correlations (p<0.001) between the yield stress and both M and M1. Thus, within the range of aggregation studied, these findings lend support to the rheological validity of the Myrenne approach; extension of our findings to intensely aggregating RBC suspensions may require additional validation studies.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalBiorheology
Volume44
Issue number1
StatePublished - 2007

Keywords

  • ESR
  • Myrenne aggregometer
  • Red cell aggregation
  • Yield stress

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