Oxidant production and regulation is becoming increasingly important in the study of vascular signaling mechanism.Alarge number of studies during the last 50 years have provided evidence that vascular preparations show alterations in contractile function over a wide range of O2 tensions that are observed in physiological systems. Based on observations that reactive oxygen species were vasoactive and appeared to have distinct signaling mechanisms, itwas suggested that these species could function in vascular O2 sensing mechanisms that mediated responses to acute changes in pO 2.1,2
Bibliographical noteFunding Information:
E. Kenneth Weir is supported by general medical research funds from the US Department of Veterans Affairs and NIH (ROI-HL 65322-01A1). The authors appreciate the intellectual contributions of Stephen L. Archer, MD and Douglas A. Peterson, MD, PhD to the concepts developed in this paper.
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