Reelin glycoprotein: Structure, biology and roles in health and disease

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Abstract

Reelin glycoprotein is a secretory serine protease with dual roles in mammalian brain: embryologically, it guides neurons and radial glial cells to their corrected positions in the developing brain; in adult brain, Reelin is involved in a signaling pathway which underlies neurotransmission, memory formation and synaptic plasticity. Disruption of Reelin signaling pathway by mutations and selective hypermethylation of the Rein gene promoter or following various pre- or postnatal insults may lead to cognitive deficits present in neuropsychiatric disorders like autism or schizophrenia.

Original languageEnglish (US)
Pages (from-to)251-257
Number of pages7
JournalMolecular psychiatry
Volume10
Issue number3
DOIs
StatePublished - Mar 2005

Bibliographical note

Funding Information:
The work of author has been supported by Stanley Medical Research Institute, March of Dimes, The Jonty Foundation and the Kunin Fund of St Paul Foundation. I am grateful for secretarial assistance by Ms Laurie Iversen and Danielle Johansson.

Keywords

  • Autism
  • Reeler mouse
  • Reelin
  • Schizophrenia

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