Reelin glycoprotein is a secretory serine protease with dual roles in mammalian brain: embryologically, it guides neurons and radial glial cells to their corrected positions in the developing brain; in adult brain, Reelin is involved in a signaling pathway which underlies neurotransmission, memory formation and synaptic plasticity. Disruption of Reelin signaling pathway by mutations and selective hypermethylation of the Rein gene promoter or following various pre- or postnatal insults may lead to cognitive deficits present in neuropsychiatric disorders like autism or schizophrenia.
Bibliographical noteFunding Information:
The work of author has been supported by Stanley Medical Research Institute, March of Dimes, The Jonty Foundation and the Kunin Fund of St Paul Foundation. I am grateful for secretarial assistance by Ms Laurie Iversen and Danielle Johansson.
- Reeler mouse