Abstract
Drugs which alter the levels of serotonin, 5 hydroxyindoleacetic acid (5 HIAA) and noradrenaline were shown to affect tryptophan hydroxylase activity in the CNS. Relatively high doses of 5 HIAA and noradrenaline added in vitro also inhibit tryptophan hydroxylase. The possibility that brain serotonin biosynthesis is regulated via and end product feedback control mechanism is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 215-219 |
| Number of pages | 5 |
| Journal | Pharmacology |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1973 |