Regulation of purine metabolism: A comparative study of the kinetic properties of adenylosuccinate synthetases from various sources

Sandra W. Clark, Susan A. Berry, Robert Ewing, Frederick B. Rudolph

Research output: Contribution to journalArticlepeer-review

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Abstract

1. 1. Adenylosuccinate synthetase has been partially purified from rat liver, fetal rat liver, Novikoff ascites cells, Walker carcinoma 256 solid tumors, chicken liver and muscle, rabbit muscle and pig brain. 2. 2. Considerable differences exist in Michaelis constants among the various species and the changes possibly reflect differences in regulation. 3. 3. The kinetic properties of the enzyme are generally consistent with proposed metabolic roles in various tissues.

Original languageEnglish (US)
Pages (from-to)63-65
Number of pages3
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume58
Issue number1
DOIs
StatePublished - 1977

Bibliographical note

Funding Information:
Acknowledoements--This research was supported in part by Grant #CA 14030 from the National Cancer Institute and Grant # C-582 from the Robert A. Welch Foundation.

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