TY - JOUR
T1 - Regulation of purine metabolism
T2 - A comparative study of the kinetic properties of adenylosuccinate synthetases from various sources
AU - Clark, Sandra W.
AU - Berry, Susan A.
AU - Ewing, Robert
AU - Rudolph, Frederick B.
N1 - Funding Information:
Acknowledoements--This research was supported in part by Grant #CA 14030 from the National Cancer Institute and Grant # C-582 from the Robert A. Welch Foundation.
PY - 1977
Y1 - 1977
N2 - 1. 1. Adenylosuccinate synthetase has been partially purified from rat liver, fetal rat liver, Novikoff ascites cells, Walker carcinoma 256 solid tumors, chicken liver and muscle, rabbit muscle and pig brain. 2. 2. Considerable differences exist in Michaelis constants among the various species and the changes possibly reflect differences in regulation. 3. 3. The kinetic properties of the enzyme are generally consistent with proposed metabolic roles in various tissues.
AB - 1. 1. Adenylosuccinate synthetase has been partially purified from rat liver, fetal rat liver, Novikoff ascites cells, Walker carcinoma 256 solid tumors, chicken liver and muscle, rabbit muscle and pig brain. 2. 2. Considerable differences exist in Michaelis constants among the various species and the changes possibly reflect differences in regulation. 3. 3. The kinetic properties of the enzyme are generally consistent with proposed metabolic roles in various tissues.
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U2 - 10.1016/0305-0491(77)90128-6
DO - 10.1016/0305-0491(77)90128-6
M3 - Article
C2 - 318261
AN - SCOPUS:0017683126
SN - 0305-0491
VL - 58
SP - 63
EP - 65
JO - Comparative Biochemistry and Physiology -- Part B: Biochemistry and
JF - Comparative Biochemistry and Physiology -- Part B: Biochemistry and
IS - 1
ER -
