PURPOSE: To examine the relationship of serum and dietary magnesium (Mg) with incident hypertension. The setting was the Atherosclerosis Risk in Communities (ARIC) Study, which included a biracial cohort, aged 45-64 years, from four U.S. communities. METHODS: This analysis included 7731 participants (4190 women and 3541 men) free of hypertension at baseline and followed six years. Fasting serum Mg was measured, and usual dietary intake was assessed with a food frequency questionnaire. RESULTS: After adjustment for age, race, and a number of other risk factors, the odds of incident hypertension across ascending quartiles of serum Mg were 1.0, 0.79, 0.85, and 0.70 in women (p trend = 0.01) and 1.0, 0.87, 0.87, and 0.82 in men (p trend = 0.16). We found no association between dietary Mg intake and incident hypertension. These associations were attenuated after the addition of baseline systolic blood pressure to the models. CONCLUSIONS: This study suggests that low Mg may play a modest role in the development of hypertension.
Bibliographical noteFunding Information:
The ARIC Study was funded by contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022 from the U.S. National Heart, Lung, and Blood Institute. The authors thank Laura Kemmis for assistance in manuscript preparation, Lori Boland, Mark Pereira, Ching-Ping Hong, Fangzi Liao, and Paul McGovern for technical assistance and helpful suggestions, and the following ARIC personnel: Phyllis Johnson, Marilyn Knowles, and Catherine Paton from the University of North Carolina, Chapel Hill, NC; Nadine Shelton, Carol Smith, Pamela Williams, and Jeannette Bensen from the University of North Carolina, Forsyth County, NC; Virginia Overman, Stephanie Parker, Liza Sullivan, and Cora Walls from the University of Mississippi Medical Center, Jackson, MS; Carolyne Campbell, Maxine Dammen, Caryl De Young, and Jaci Dion from the University of Minnesota, Minneapolis, MN; Joan Nelling, Thelma Oliver, Rodney Palmer, and Serena Bell from the Johns Hopkins University, Baltimore, MD; Valarie Stinson, Pam Pfile, Hogan Pham, and Teri Trevino from the University of Texas Medical School, Houston, TX; Wanda Alexander, Doris Harper, Charles Rhodes, and Selma Soyal from the Methodist Hospital, Atherosclerosis Clinical Laboratory, Houston, TX; Kathy Joyce, Mary Lauffer, Suzanne Pillsbury, and Tiffany Robertson from the Bowman-Gray School of Medicine, Ultrasound Reading Center, Winston-Salem, NC; and Jeff Abolofia, Hope Bryan, Myra Carpenter, and Limin Clegg from the ARIC Coordinating Center, University of North Carolina, Chapel Hill, NC.
Copyright 2007 Elsevier B.V., All rights reserved.
- Blood Pressure
- Prospective Study