Abstract
The main cause of acute kidney injury in patients receiving immune checkpoint inhibitors (ICIs) is acute interstitial nephritis. However, as their use continues to increase, other kidney manifestations are being described. We report 3 cases of patients treated with ICIs who developed predominantly electrolyte disorders secondary to renal tubular acidosis as an immune-related adverse event and discuss the potential mechanism. Nongap acidosis in combination with hypokalemia should raise suspicion for distal renal tubular acidosis in patients treated with ICIs.
Original language | English (US) |
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Pages (from-to) | 657-662 |
Number of pages | 6 |
Journal | Kidney Medicine |
Volume | 2 |
Issue number | 5 |
DOIs | |
State | Published - Sep 1 2020 |
Bibliographical note
Funding Information:Dr Herrmann is supported by K08 DK118120 and by Mary Kathryn and Michael B. Panitch Career Development Award. Dr Romero is supported by P30-DK090278 , R01-DK092408 , EY017732 , R25-DK101405 , the Oxalosis and Hyperoxaluria Foundation , and the Mayo Foundation .
Publisher Copyright:
© 2020 The Authors
Keywords
- Immune checkpoint inhibitors
- PD-1 inhibitor
- acute interstitial nephritis
- case report
- immune-related adverse event
- renal tubular acidosis